Overexpression and diffuse expression pattern of IQGAP1 at invasion fronts are independent prognostic parameters in ovarian carcinomas

被引：55

作者：

Dong, Peixin

Nabeshima, Kazuki

Nishimura, Naoko

Kawakami, Takehito

Hachisuga, Toru

Kawarabayashi, Tatsuhiko

Iwasaki, Hiroshi

机构：

[1] Fukuoka Univ Hosp, Dept Pathol, Jonan Ku, Fukuoka 8140180, Japan

[2] Fukuoka Univ, Sch Med, Jonan Ku, Fukuoka 8140180, Japan

[3] Fukuoka Univ Hosp, Dept Obstet & Gynecol, Jonan Ku, Fukuoka 8140180, Japan

来源：

CANCER LETTERS | 2006年 / 243卷 / 01期

关键词：

IQGAP1; ovarian carcinoma; cell adhesion; cytoskeleton; tumor invasion; metastasis;

D O I：

10.1016/j.canlet.2005.11.024

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

IQGAP1 is a multifunctional protein involved in actin cytoskeleton assembly and E-cadherin-mediated cell adhesion. To determine the role of IQGAP1 in ovarian tumors, we evaluated IQGAP1 expression by immunohistochemistry in 17 adenomas, 30 borderline tumors and 80 adenocarcinomas and its relation with patient survival. IQGAP1 was overexpressed in adenocarcinomas compared with adenomas and borderline tumors. Enhanced immunostaining in invasive tumor fronts was categorized as focal or diffuse. The diffuse expression pattern correlated with high histological grade and clinicopathological stages. IQGAP1 overexpression and diffuse invasion pattern were significantly associated with poor prognosis by multivariate analysis. Our findings suggest the involvement of IQGAP1 in the progression and spread of ovarian adenocarcinomas. Overexpression and diffuse expression pattern of IQGAP1 are potentially useful independent molecular predictors of highly aggressive ovarian carcinomas. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：120 / 127

页数：8

共 36 条

[1] High levels of MMP-2, MMP-9, MT1-MMP and TIMP-2 mRNA correlate with poor survival in ovarian carcinoma [J].