Polymers and proteins: Interactions at interfaces

被引:168
作者
Szleifer, I
机构
[1] Department of Chemistry, Purdue University, West Lafayette
基金
美国国家科学基金会;
关键词
D O I
10.1016/S1359-0286(97)80125-8
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
The ability of polymer molecules attached at one end to a surface to prevent or enhance protein adsorption has been studied experimentally and theoretically. Recent systematic studies show that surface density seems to be the most important property of the tethered layer that determines its ability to prevent protein adsorption. Theoretical studies predict that the interactions of the polymer layer with the proteins and the adsorption behavior do not depend in the same way on polymer molecular weight and on the type of interaction of the polymer with the surface.
引用
收藏
页码:337 / 344
页数:8
相关论文
共 38 条
[1]   TETHERED ADSORBING CHAINS - NEUTRON REFLECTIVITY AND SURFACE PRESSURE OF SPREAD DIBLOCK COPOLYMER MONOLAYERS [J].
BIJSTERBOSCH, HD ;
DEHAAN, VO ;
DEGRAAF, AW ;
MELLEMA, M ;
LEERMAKERS, FAM ;
STUART, MAC ;
VANWELL, AA .
LANGMUIR, 1995, 11 (11) :4467-4473
[2]  
CASTILLO E, 1986, BIOMATERIALS, V6, P338
[3]   Surface treatments of polymers for biocompatibility [J].
Elbert, DL ;
Hubbell, JA .
ANNUAL REVIEW OF MATERIALS SCIENCE, 1996, 26 :365-394
[4]   THE CONTROLLED INTRAVENOUS DELIVERY OF DRUGS USING PEG-COATED STERICALLY STABILIZED NANOSPHERES [J].
GREF, R ;
DOMB, A ;
QUELLEC, P ;
BLUNK, T ;
MULLER, RH ;
VERBAVATZ, JM ;
LANGER, R .
ADVANCED DRUG DELIVERY REVIEWS, 1995, 16 (2-3) :215-233
[5]  
Grest G.S., 1995, MONTE CARLO MOL DYNA, P476
[6]  
HALPERIN A, 1994, NATO ADV SCI INST SE, V323, P33
[7]  
Harris J.M., 1992, Polyethylene Glycol: Chemistry and Biological Applications
[8]   Hemocompatible cellulose dialysis membranes modified with phospholipid polymers [J].
Ishihara, K ;
Nakabayashi, N .
ARTIFICIAL ORGANS, 1995, 19 (12) :1215-1221
[9]  
Ishihara K, 1996, J POLYM SCI POL CHEM, V34, P199, DOI 10.1002/(SICI)1099-0518(19960130)34:2<199::AID-POLA6>3.0.CO
[10]  
2-P