Opinion - Angiogenesis: an organizing principle for drug discovery?

被引:1788
作者
Folkman, Judah [1 ]
机构
[1] Harvard Univ, Sch Med, Childrens Hosp, Boston, MA 02115 USA
关键词
ENDOTHELIAL GROWTH-FACTOR; ANTIANGIOGENIC THERAPY; BREAST-CANCER; TUMOR-GROWTH; ENDOGENOUS INHIBITORS; INTERFERON-ALPHA; FACTOR VEGF; MATRIX METALLOPROTEINASES; INTRAVITREAL INJECTION; TARGETING ANGIOGENESIS;
D O I
10.1038/nrd2115
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 [微生物学]; 090105 [作物生产系统与生态工程];
摘要
Angiogenesis - the process of new blood-vessel growth - has an essential role in development, reproduction and repair. However, pathological angiogenesis occurs not only in tumour formation, but also in a range of nonneoplastic diseases that could be classed together as 'angiogenesis-dependent diseases'. By viewing the process of angiogenesis as an 'organizing principle' in biology, intriguing insights into the molecular mechanisms of seemingly unrelated phenomena might be gained. This has important consequences for the clinical use of angiogenesis inhibitors and for drug discovery, not only for optimizing the treatment of cancer, but possibly also for developing therapeutic approaches for various diseases that are otherwise unrelated to each other.
引用
收藏
页码:273 / 286
页数:14
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