Novel L-Xylose Derivatives as Selective Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitors for the Treatment of Type 2 Diabetes

被引：70

作者：

Goodwin, Nicole C. ^{[1
]}

Mabon, Ross ^{[1
]}

Harrison, Bryce A. ^{[1
]}

Shadoan, Melanie K. ^{[2
]}

Almstead, Zheng Y. ^{[1
]}

Xie, Yiling ^{[1
]}

Healy, Jason ^{[1
]}

Buhring, Lindsey M. ^{[2
]}

DaCosta, Christopher M. ^{[2
]}

Bardenhagen, Jennifer ^{[3
]}

Mseeh, Faika ^{[3
]}

Liu, Qingyun ^{[3
]}

Nouraldeen, Amr ^{[4
]}

Wilson, Alan G. E. ^{[4
]}

Kimball, S. David ^{[1
]}

Powell, David R. ^{[2
]}

Rawlins, David B. ^{[1
]}

机构：

[1] Lexicon Pharmaceut, Dept Med Chem, Princeton, NJ 08540 USA

[2] Lexicon Pharmaceut, Dept Metab & Cardiol, The Woodlands, TX 77381 USA

[3] Lexicon Pharmaceut, Dept Pharmaceut Discovery, The Woodlands, TX 77381 USA

[4] Lexicon Pharmaceut, Dept Drug Metab Pharmacokinet & Toxicol, The Woodlands, TX 77381 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2009年 / 52卷 / 20期

关键词：

RECESSIVE RENAL GLUCOSURIA; NA+/GLUCOSE COTRANSPORTER; GALACTOSE MALABSORPTION; DAPAGLIFLOZIN; MECHANISM; MELLITUS; KIDNEY; MOUSE;

D O I：

10.1021/jm900951n

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The prevalence of diabetes throughout the world continues to increase and has become a major health issue. Recently there have been several reports of inhibitors directed toward the sodium-dependent glucose cotransporter 2 (SGLT2) as a method of maintaining glucose homeostasis in diabetic patients. Herein we report the discovery of the novel O-xyloside 7c that inhibits SGLT2 in vitro and urinary glucose reabsorption in vivo.

引用

页码：6201 / 6204

页数：4

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