Caspase substrates and neurodegenerative diseases

被引：31

作者：

Bulat, Natasa ^{[1
,2
]}

Widmann, Christian ^{[1
,2
]}

机构：

[1] Univ Lausanne, Dept Physiol, CH-1005 Lausanne, Switzerland

[2] Univ Lausanne, Dept Cell Biol & Morphol, CH-1005 Lausanne, Switzerland

来源：

BRAIN RESEARCH BULLETIN | 2009年 / 80卷 / 4-5期

基金：

瑞士国家科学基金会;

关键词：

Neurodegenerative diseases; Caspases; Substrates; Apoptosis; Survival; Huntingtin; APP; Tau; Preselinins; RasGAP; Rb; PARP; AMYLOID PRECURSOR PROTEIN; N-TERMINAL FRAGMENTS; ALZHEIMERS-DISEASE; MUTANT HUNTINGTIN; WILD-TYPE; MOUSE MODEL; CELL-DEATH; POLY(ADP-RIBOSE) POLYMERASE; NEUROFIBRILLARY TANGLES; TAU CLEAVAGE;

D O I：

10.1016/j.brainresbull.2009.07.007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Apoptosis is induced by the cleavage of a subset of cellular proteins by proteases of the caspase family. Numerous (hundreds) caspase substrates have been described but only for a few of them is the function of their cleavage by caspases well understood. In this review, apoptosis and caspases will first be introduced. The main focus will then be directed to the caspase substrates, the actual "workers" doing the job of mediating and regulating the apoptotic process. The caspase substrates whose functions upon cleavage have been carefully investigated and those that are potentially involved in neurodegenerative diseases will be discussed in detail. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：251 / 267

页数：17

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