Pathways for mRNA localization in the cytoplasm

被引：89

作者：

Czaplinski, Kevin ^{[1
]}

Singer, Robert H. ^{[1
]}

机构：

[1] Albert Einstein Coll Med, Dept Anat & Struct Biol, Bronx, NY 10461 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2006年 / 31卷 / 12期

关键词：

D O I：

10.1016/j.tibs.2006.10.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Studies of the intracellular localization of mRNA have clearly demonstrated that certain subsets of mRNA are concentrated in discrete locations within the cytoplasm. Localization is one aspect of the post-transcriptional control of gene expression, and is intertwined with the translation and turnover of mRNA to achieve the goal of local protein production. Different mechanisms have been identified that enable localized mRNAs to target different subcellular compartments, and recent advances in understanding these pathways is reviewed here.

引用

页码：687 / 693

页数：7

共 71 条

[1]

Transport and localization elements in myelin basic protein mRNA [J].

Ainger, K ;

Avossa, D ;

Diana, AS ;

Barry, C ;

Barbarese, E ;

Carson, JH .

JOURNAL OF CELL BIOLOGY, 1997, 138 (05) :1077-1087

[2]

Two distinct Staufen isoforms in Xenopus are vegetally localized during oogenesis [J].

Allison, R ;

Czaplinski, K ;

Git, A ;

Adegbenro, E ;

Stennard, F ;

Houliston, E ;

Standart, N .

RNA, 2004, 10 (11) :1751-1763

[3]

Recognition of a bicoid mRNA localization signal by a protein complex containing swallow, Nod, and RNA binding proteins [J].

Arn, EA ;

Cha, BJ ;

Theurkauf, WE ;

Macdonald, PM .

DEVELOPMENTAL CELL, 2003, 4 (01) :41-51

[4]

Cytoplasmic polyadenylation element binding protein-dependent protein synthesis is regulated by calcium/calmodulin-cependent protein kinase II [J].

Atkins, CM ;

Nozaki, N ;

Shigeri, Y ;

Soderling, TR .

JOURNAL OF NEUROSCIENCE, 2004, 24 (22) :5193-5201

[5]

Joint action of two RNA degradation pathways controls the timing of maternal transcript elimination at the midblastula transition in Drosophila melanogaster [J].

Bashirullah, A ;

Halsell, SR ;

Cooperstock, RL ;

Kloc, M ;

Karaiskakis, A ;

Fisher, WW ;

Fu, WL ;

Hamilton, JK ;

Etkin, LD ;

Lipshitz, HD .

EMBO JOURNAL, 1999, 18 (09) :2610-2620

[6]

Kinesin II mediates Vg1 mRNA transport in Xenopus oocytes [J].

Betley, JN ;

Heinrich, B ;

Vernos, I ;

Sardet, C ;

Prodon, F ;

Deshler, JO .

CURRENT BIOLOGY, 2004, 14 (03) :219-224

[7]

A function for kinesin I in the posterior transport of oskar mRNA and Staufen protein [J].

Brendza, RP ;

Serbus, LR ;

Duffy, JB ;

Saxton, WM .

SCIENCE, 2000, 289 (5487) :2120-2122

[8]

Carson JH, 1997, CELL MOTIL CYTOSKEL, V38, P318, DOI 10.1002/(SICI)1097-0169(1997)38:4<318::AID-CM2>3.0.CO

[9]

2-#

[10]

Kinesin I-dependent cortical exclusion restricts pole plasm to the oocyte posterior [J].

Cha, BJ ;

Serbus, LR ;

Koppetsch, BS ;

Theurkauf, WE .

NATURE CELL BIOLOGY, 2002, 4 (08) :592-598

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