Therapeutic drug monitoring opportunities in cancer therapy

被引:23
作者
McLeod, HL
机构
[1] Department of Medicine and Therap., University of Aberdeen, Polworth Building, Aberdeen AB25 2ZD, Foresterhill
关键词
therapeutic drug monitoring; cancer therapeutics; pharmacokinetics; cancer chemotherapy;
D O I
10.1016/S0163-7258(96)00201-X
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Cancer is a common cause of death, and improvements in treatment are desperately needed. The high degree of variation in systemic exposure far a given dose and the relationships between blood concentrations and either toxic or antitumor effects would suggest that therapeutic drug monitoring is a potential mechanism for improving the treatment of individual patients. In this review, the case for therapeutic drug monitoring is made in a select number of commonly used cancer drugs and areas that require more concerted effort are highlighted. (C) 1997 Elsevier Science Inc.
引用
收藏
页码:39 / 54
页数:16
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