Efficient access to ATP mimics, potential FGF receptor tyrosine kinase inhibitors

被引：12

作者：

Rigolet, S ^{[1
]}

McCort, I ^{[1
]}

Le Merrer, Y ^{[1
]}

机构：

[1] Univ Paris 05, Chim & Biochim Pharmacol & Toxicol Lab, UMR 8601, F-75270 Paris 06, France

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 45期

关键词：

bis-epoxide; boron trifluoride etherate; lithiation; transmetalation; tyrosine kinase;

D O I：

10.1016/S0040-4039(02)01923-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Nucleophilic opening of bis-epoxide 1 derived from D-mannitol by organolithium species in the presence of boron trifluoride etherate allows the synthesis of enantiopure polyhydroxy tetrahydrofurane skeletons with aromatic moieties in the pseuwdo-anomeric position, ortho-Lithiation and transmetalation are the most appropriate conditions for the preparation of the organometallic derivatives where halogen-metal exchange is unfavorable. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：8129 / 8132

页数：4

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