Brucella proteomes -: a review

被引：22

作者：

DelVecchio, VG ^{[1
]}

Wagner, MA

Eschenbrenner, M

Horn, TA

Kraycer, JA

Estock, F

Elzer, P

Mujer, CV

机构：

[1] Univ Scranton, Inst Mol Biol & Med, Scranton, PA 18510 USA

[2] Louisiana State Univ, AgCtr, Dept Vet Sci, Baton Rouge, LA 70803 USA

来源：

VETERINARY MICROBIOLOGY | 2002年 / 90卷 / 1-4期

关键词：

Brucella melitensis; Brucella abortus; proteome; Rev 1 vaccine strain;

D O I：

10.1016/S0378-1135(02)00239-0

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The proteomes of selected Brucella spp. have been extensively analyzed by utilizing current proteomic technology involving 2-DE and MALDI-MS. In Brucella melitensis, more than 500 proteins were identified. The rapid and large-scale identification of proteins in this organism was accomplished by using the annotated B. melitensis genome which is now available in the GenBank. Coupled with new and powerful tools for data analysis, differentially expressed proteins were identified and categorized into several classes. A global over-view of protein expression patterns emerged, thereby facilitating the simultaneous analysis of different metabolic pathways in B. melitensis. Such a global characterization would not have been possible by using time consuming and traditional biochemical approaches. The era of post-genomic technology offers new and exciting opportunities to understand the complete biology of different Brucella species. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：593 / 603

页数：11

共 36 条

[1] A review of the use of B-melitensis Rev 1 vaccine in adult sheep and goats [J].

Blasco, JM .

PREVENTIVE VETERINARY MEDICINE, 1997, 31 (3-4) :275-283

[2] SODIUM DODECYL SULFATE-EXTRACTED AND SALT-EXTRACTED ANTIGENS FROM VARIOUS BRUCELLA SPECIES INDUCE PROLIFERATION OF BOVINE LYMPHOCYTES [J].

BROOKSWORRELL, BM ;

SPLITTER, GA .

INFECTION AND IMMUNITY, 1992, 60 (05) :2136-2138

[3]

Corbel M.J., 1984, Bergey Manual of Systematic Bacteriology, P377

[4] Brucellosis: An overview [J].

Corbel, MJ .

EMERGING INFECTIOUS DISEASES, 1997, 3 (02) :213-221

[5]

Cordwell SJ, 2001, PROTEOMICS, V1, P461, DOI 10.1002/1615-9861(200104)1:4<461::AID-PROT461>3.3.CO

[6]

2-J

[7] The genome sequence of the facultative intracellular pathogen Brucella melitensis [J].

DelVecchio, VG ;

Kapatral, V ;

Redkar, RJ ;

Patra, G ;

Mujer, C ;

Los, T ;

Ivanova, N ;

Anderson, I ;

Bhattacharyya, A ;

Lykidis, A ;

Reznik, G ;

Jablonski, L ;

Larsen, N ;

D'Souza, M ;

Bernal, A ;

Mazur, M ;

Goltsman, E ;

Selkov, E ;

Elzer, PH ;

Hagius, S ;

O'Callaghan, D ;

Letesson, JJ ;

Haselkorn, R ;

Kyrpides, N ;

Overbeek, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (01) :443-448

[8] IMMUNIZATION AGAINST BRUCELLA INFECTION .6. IMMUNITY CONFERRED ON GOATS BY A NONDEPENDENT MUTANT FROM A STREPTOMYCIN-DEPENDENT MUTANT STRAIN OF BRUCELLA-MELITENSIS [J].

ELBERG, SS ;

FAUNCE, K .

JOURNAL OF BACTERIOLOGY, 1957, 73 (02) :211-217

[9]

Enright F. M., 1990, Animal brucellosis., P301

[10]

ESCHENBRENNER M, 2002, COMP PROTEOME ANAL B, V184, P4962

← 1 2 3 4 →