Endogenous mutagenesis and cancer

被引:18
作者
Davidson, JF [1 ]
Guo, HWH [1 ]
Loeb, LA [1 ]
机构
[1] Univ Washington, Joseph Gottstein Mem Canc Res Lab, Dept Pathol, Seattle, WA 98195 USA
关键词
mutagenesis; mutator; stem cell; cancer;
D O I
10.1016/S0027-5107(02)00228-2
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Mutations in DNA accrue relentlessly, largely via stochastic processes. Random changes accumulate, eventually disabling genetic components which result in the formation of the cancer phenotype. Given the infrequency of measured nucleotide changes and the requirement for several mutations to occur in the same cell, it has been postulated that the rate of mutation must become elevated early in the course of evolution of the cancer. Recently, large scale sequencing of tumor DNA has sought to directly measure random mutations. We discuss the implications of these findings and the factors that must be considered in order for fruitful determination of whether a mutator phenotype is a necessary precursor for cancer. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:17 / 21
页数:5
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