Bruchins: Insect-derived plant regulators that stimulate neoplasm formation

被引:180
作者
Doss, RP [1 ]
Oliver, JE
Proebsting, WM
Potter, SW
Kuy, SR
Clement, SL
Williamson, RT
Carney, JR
DeVilbiss, ED
机构
[1] USDA ARS, Hort Crops Res Unit, Corvallis, OR 97330 USA
[2] Oregon State Univ, Dept Hort, Corvallis, OR 97331 USA
[3] Oregon State Univ, Dept Zool, Corvallis, OR 97331 USA
[4] Oregon State Univ, Coll Pharm, Corvallis, OR 97331 USA
[5] USDA ARS, Beltsville Agr Res Ctr, Insect Chem Ecol Lab, Beltsville, MD 20705 USA
[6] USDA ARS, Reg Plant Introduct Stn, Pullman, WA 99164 USA
[7] KOSAN Biosci, Hayward, CA 94545 USA
关键词
D O I
10.1073/pnas.110054697
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Pea weevil (Brochus pisorum L.) oviposition on pods of specific genetic lines of pea (Pisum sativum L.) stimulates cell division at the sites of egg attachment. As a result, tumor-like growths of undifferentiated cells (neoplasms) develop beneath the egg. These neoplasms impede larval entry into the pod. This unique form of induced resistance is conditioned by the Np allele and mediated by a recently discovered class of natural products that we have identified from both cowpea weevil (Callosobruchus maculatus F,) and pea weevil, These compounds, which we refer to as "bruchins," are long-chain alpha,omega-diols, esterified at one or both oxygens with 3-hydroxypropanoic acid. Bruchins are potent plant regulators, with application of as little as 1 fmol (0.5 pg) causing neoplastic growth on pods of all of the pea lines tested. The bruchins are, to our knowledge, the first natural products discovered with the ability to induce neoplasm formation when applied to intact plants.
引用
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页码:6218 / 6223
页数:6
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