Calpain3 expression during human cardiogenesis

被引:24
作者
Fougerousse, F
Anderson, LVB
Delezoide, AL
Suel, L
Durand, M
Beckmann, JS
机构
[1] Genethon, URA 1922, F-91002 Evry, France
[2] Univ Newcastle Upon Tyne, Sch Med, Dept Neurobiol, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
[3] Necker Hosp, Serv Histol Embryol & Cytogenet, F-75015 Paris, France
关键词
human development; calpain3; titin; limb girdle muscular dystrophy; cardiogenesis;
D O I
10.1016/S0960-8966(99)00107-8
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Transcripts of calpain3, the gene involved in limb girdle muscular dystrophy type 2A, appear in organs other than the skeletal muscle during human development, the first of which bring the early embryonic heart. We examined more precisely the spatio-temporal transcription pattern of calpain3 during human cardiogenesis and the appearance of its protein ih fetal tissues, and correlated it to titin expression. Different events of the heart's maturation can be recognized: (i) the presence of titin RNA or protein constitute very precocious developmental cardiac markers appearing before the fusion of the two lateral endocardial tubes; (ii) the disappearance of calpain3 RNA from the ventricular compartment later in the embryonic heart. Finally, although calpain3 transcripts are present in the heart, the corresponding protein is not detected elsewhere than in skeletal muscle. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:251 / 256
页数:6
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