Short telomeres are preferentially elongated by telomerase in human cells

被引：44

作者：

Britt-Compton, Bethan ^{[1
]}

Capper, Rebecca ^{[1
]}

Rowson, Jan ^{[1
]}

Baird, Duncan M. ^{[1
]}

机构：

[1] Cardiff Univ, Dept Pathol, Sch Med, Cardiff CF14 4XN, S Glam, Wales

来源：

FEBS LETTERS | 2009年 / 583卷 / 18期

关键词：

Telomere; Telomerase; Senescence; Replicative lifespan; Cancer; LENGTH HOMEOSTASIS; STABILITY;

D O I：

10.1016/j.febslet.2009.08.029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Short telomeres have been shown to be preferentially elongated in both yeast and mouse models. We examined this in human cells, by utilising cells with large allelic telomere length differentials and observing the relative rates of elongation following the expression of hTERT. We observed that short telomeres are gradually elongated in the first 26 PDs of growth, whereas the longer telomeres displayed limited elongation in this period. Telomeres coalesced at similar lengths irrespective of their length prior to the expression of hTERT. These data indicate that short telomeres are marked for gradual elongation to a cell strain specific length threshold. (C) 2009 Published by Elsevier B. V. on behalf of the Federation of European Biochemical Societies.

引用

页码：3076 / 3080

页数：5

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