Nanoparticle-mediated drug delivery and gene therapy

被引:196
作者
Jin, Sha
Ye, Kaiming [1 ]
机构
[1] Univ Arkansas, Coll Engn, DNA Resource Ctr, Fayetteville, AR 72701 USA
[2] Univ Arkansas, Coll Engn, Biomed Engn Program, Fayetteville, AR 72701 USA
关键词
D O I
10.1021/bp060348j
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Biomedical application of nanotechnology is a rapidly developing area that raises new prospect in the improvement of diagnosis and treatment of human diseases. The ability to incorporate drugs or genes into a functionalized nanoparticle demonstrates a new era in pharmacotherapy for delivering drugs or genes selectively to tissues or cells. It is envisioned that the transfer of nanoengineering capability into disease therapy will provide constant and concentrated drug delivery to targeted tissues, minimizing systemic side effects and toxicity. We have in this article highlighted the recent state of the art in nanomedicine, focusing particularly on the achievement of nanotechnology in nanoscale drug and gene delivery in vitro and in vivo. In addition, a specific emphasis has been placed on the use of nanotechnology to improve controlled drug release and sustainable drug delivery in solid tumors and on new drug therapies for age-related neurodegenerative disorders.
引用
收藏
页码:32 / 41
页数:10
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