Telomerase beyond telomeres

被引：143

作者：

Blasco, MA ^{[1
]}

机构：

[1] Natl Biotechnol Ctr, Dept Immunol & Oncol, E-28049 Madrid, Spain

来源：

NATURE REVIEWS CANCER | 2002年 / 2卷 / 08期

关键词：

D O I：

10.1038/nrc862

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The role of telomerase in actively proliferating cells is assumed to be restricted to maintaining of telomeres above a minimum-length threshold, thereby preventing telomere exhaustion and chromosomal instability. However, forced telomerase expression in cells and mice with normal-length telomeres has shown that telomerase promotes growth and survival in a manner that is uncoupled from net telomere lengthening. These findings imply that telomerase might have a fundamental role in tumour growth and survival, even at stages when telomeres are sufficiently long.

引用

页码：627 / 632

页数：6

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