Genes, mitochondria and aging in filamentous fungi

被引：60

作者：

Osiewacz, HD ^{[1
]}

机构：

[1] Goethe Univ Frankfurt, Inst Bot, D-60439 Frankfurt, Germany

来源：

AGEING RESEARCH REVIEWS | 2002年 / 1卷 / 03期

关键词：

filamentous fungi; mitochondria; oxidative stress; molecular damage; remodeling;

D O I：

10.1016/S1568-1637(02)00010-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Fungi are eukaryotic microorganisms studied in various areas of general and applied biology. A few species were among the first systems in which specific aspects of aging were addressed experimentally. Various factors, both environmental and genetic, were found to affect lifespan and aging. Mitochondrial pathways play a paramount role. Since mitochondria are semiautonomous organelles and depend on both nuclear as well as mitochondrial genes, mitochondrial-nuclear interactions are of major relevance. As a main generator of reactive oxygen species (ROS), mitochondria are prone to molecular damage. However, cells can cope with the negative effects of ROS utilizing different scavenging systems and, once defects became manifested, by repair of damaged molecules. Both, lowering ROS generation and increasing mitochondrial "caretaker" systems bear great potential to interfere with natural aging processes. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：425 / 442

页数：18

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