Repeated administration intensifies the reinforcing effect of fencamfamine in rats

被引：5

作者：

DeLucia, R ^{[1
]}

Planeta, CS ^{[1
]}

Aizenstein, ML ^{[1
]}

Scavone, C ^{[1
]}

机构：

[1] UNIV ESTADUAL PAULISTA,FAC CIENCIAS FARMACEUT,DEPT PRINCIPIOS ATIVOS NAT & TOXICOL,BR-14801902 ARARAQUARA,SP,BRAZIL

来源：

GENERAL PHARMACOLOGY | 1997年 / 29卷 / 02期

关键词：

fencamfamine; psychostimulant; sensitization; place conditioning; reinforcing effect;

D O I：

10.1016/S0306-3623(96)00414-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. In the present study, we evaluated the role of repeated administration on conditioning place preference (CPP) induced by fencamfamine (FCF) in male rats. 2. Repeated FCF (3.5 mg/kg) or saline once or daily for ten consecutive days enhanced sniffing du ration and decreased locomotion and rearing duration. 3. At the 3.5 mg/kg dose, FCF produced a significant place-preference effect. 4. Repeated exposures to FCF intensified its reinforcing properties. 5. These results suggest that repeated FCF administration sensitizes its rewarding effects, as with other addictive substances. GEN PHARMAC 29;2:265-261, 1997. (C) 1997 Elsevier Science Inc.

引用

页码：265 / 267

页数：3

共 24 条

[1] SCH 23390 BLOCKS DRUG-CONDITIONED PLACE-PREFERENCE AND PLACE-AVERSION - ANHEDONIA (LACK OF REWARD) OR APATHY (LACK OF MOTIVATION) AFTER DOPAMINE-RECEPTOR BLOCKADE [J].

ACQUAS, E ;

CARBONI, E ;

LEONE, P ;

DICHIARA, G .

PSYCHOPHARMACOLOGY, 1989, 99 (02) :151-155

[2]

AIZENSTEIN ML, 1990, NEUROPSYCHOPHARMACOL, V3, P283

[3]

AIZENSTEIN ML, 1995, BRAZ J MED BIOL RES, V28, P995

[4]

AIZENSTEIN ML, 1993, BRASIL US BINATIONAL, P9

[5] EVIDENCE FOR THE REWARDING EFFECTS OF ETHANOL USING THE CONDITIONED PLACE PREFERENCE METHOD [J].

BOZARTH, MA .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1990, 35 (02) :485-487

[6] DETECTION AND METABOLISM OF FENCAMFAMINE AND THE INFLUENCE OF ACETAZOLAMIDE ON ITS URINARY-EXCRETION [J].

DELBEKE, FT ;

DEBACKERE, M .

BIOPHARMACEUTICS & DRUG DISPOSITION, 1981, 2 (01) :17-30

[7] THE EFFECTS OF CHRONIC TREATMENT WITH FENCAMFAMINE ON BODY-WEIGHT, FOOD-INTAKE AND STEREOTYPED BEHAVIOR IN RATS [J].

DELUCIA, R ;

AIZENSTEIN, ML ;

SCAVONE, C ;

PLANETA, CD .

GENERAL PHARMACOLOGY, 1987, 18 (03) :299-301

[8] ON THE MECHANISM OF CENTRAL STIMULATION ACTION OF FENCAMFAMINE [J].

DELUCIA, R ;

BERNARDI, MM ;

SCAVONE, C ;

AIZENSTEIN, ML .

GENERAL PHARMACOLOGY, 1984, 15 (05) :407-410

[9]

DELUCIA R, 1989, Revista ABP-APAL (Associacao Brasileira de Psiquiatria-Asociacion Psiquiatrica de la America Latina), V11, P111

[10] AN OBSERVATIONAL METHOD FOR QUANTIFYING THE BEHAVIORAL-EFFECTS OF DOPAMINE AGONISTS - CONTRASTING EFFECTS OF D-AMPHETAMINE AND APOMORPHINE [J].

FRAY, PJ ;

SAHAKIAN, BJ ;

ROBBINS, TW ;

KOOB, GF ;

IVERSEN, SD .

PSYCHOPHARMACOLOGY, 1980, 69 (03) :253-259

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