The nuclear envelopathies and human diseases

被引：43

作者：

Chi, Ya-Hui ^{[2
]}

Chen, Zi-Jie ^{[2
]}

Jeang, Kuan-Teh ^{[1
]}

机构：

[1] NIAID, Mol Virol Sect, Mol Microbiol Lab, NIH, Bethesda, MD 20892 USA

[2] Natl Hlth Res Inst, Inst Cellular & Syst Med, Zhunan 35053, Taiwan

来源：

JOURNAL OF BIOMEDICAL SCIENCE | 2009年 / 16卷

关键词：

DREIFUSS MUSCULAR-DYSTROPHY; SPINDLE ASSEMBLY CHECKPOINT; LAMIN-A; MISSENSE MUTATIONS; MEMBRANE-PROTEINS; GENE; A/C; SUN1; EXPRESSION; TELOMERES;

D O I：

10.1186/1423-0127-16-96

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The nuclear envelope (NE) consists of two membrane layers that segregate the nuclear from the cytoplasmic contents. Recent progress in our understanding of nuclear-lamina associated diseases has revealed intriguing connections between the envelope components and nuclear processes. Here, we review the functions of the nuclear envelope in chromosome organization, gene expression, DNA repair and cell cycle progression, and correlate deficiencies in envelope function with human pathologies.

引用

页数：8

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