Preparation and characterization of macroporous Poly(N-isopropylacrylamide) hydrogels for the controlled release of proteins

被引：105

作者：

Zhuo, RX ^{[1
]}

Li, W ^{[1
]}

机构：

[1] Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China

来源：

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY | 2003年 / 41卷 / 01期

关键词：

poly(N-isopropylacrylamide) (PNIPAAm); hydrogels; macroporous polymers; kinetics (polym.); controlled release;

D O I：

10.1002/pola.10570

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Macroporous, temperature-sensitive poly(N-isopropylacrylamide) (PNIPA-Am) hydrogels were synthesized with poly(ethylene glycol)s (PEGS; molecular weight = 2000-6000) as the pore-forming agents. The influence of the molecular weight and PEG content on the responsive kinetics of these macroporous hydrogels was investigated. The PEG-modified PNIPAAm hydrogels were characterized by the swelling ratio, deswelling-reswelling kinetics, Fourier transform infrared, and differential scanning calorimetry. The morphology of these hydrogels was analyzed with scanning electron microscopy. The prepared macroporous hydrogels exhibited some unique proper-ties in comparison with the gels with low molecular weight PEGS (molecular weight < 2000) as the pore-forming agents. In addition, a preliminary study on the controlled release of bovine serum albumin from these macroporous hydrogels was carried out. (C) 2002 Wiley Periodicals, Inc.

引用

页码：152 / 159

页数：8

共 15 条

[1] Synthesis of in situ cross-linkable macroporous biodegradable poly(propylene fumarate-co-ethylene glycol) hydrogels [J].