Synthesis and biological activity of peptidyl aldehyde urokinase inhibitors

被引：43

作者：

Tamura, SY ^{[1
]}

Weinhouse, MI ^{[1
]}

Roberts, CA ^{[1
]}

Goldman, EA ^{[1
]}

Masukawa, K ^{[1
]}

Anderson, SM ^{[1
]}

Cohen, CR ^{[1
]}

Bradbury, AE ^{[1
]}

Bernardino, VT ^{[1
]}

Dixon, SA ^{[1
]}

Ma, MG ^{[1
]}

Nolan, TG ^{[1
]}

Brunck, TK ^{[1
]}

机构：

[1] Corvas Int Inc, Dept Med Chem, San Diego, CA 92121 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 09期

关键词：

D O I：

10.1016/S0960-894X(00)00149-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Solid- and solution-phase synthesis of peptidomimetic inhibitors of urokinase-type plasminogen activator based on the sequence dSerAlaArg-al are described. The biological activities of these unique inhibitors are reported herein. Carbonate prodrugs were prepared and tested as potential drug delivery systems. (C) 2000 Published by Elsevier Science Ltd.

引用

页码：983 / 987

页数：5

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