Deuterated phytoestrogen flavonoids and isoflavonoids for quantitation

被引：25

作者：

Wähälä, K ^{[1
]}

Rasku, S ^{[1
]}

Parikka, K ^{[1
]}

机构：

[1] Univ Helsinki, Dept Chem, Organ Chem Lab, FIN-00014 Helsinki, Finland

来源：

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2002年 / 777卷 / 1-2期

关键词：

reviews; phyroestrogens; flavonoids; isoflavonoids;

D O I：

10.1016/S1570-0232(02)00096-X

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Isotopically and isomerically pure polydeuterated flavonoids and isoflavonoids have been prepared for quantitation of these compounds in biological matrices. Various deutero-labeling techniques are presented and methods for establishing the isotopical and isomerical purity of deuterated products are discussed. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：111 / 122

页数：12

共 61 条

[1] DETERMINATION OF URINARY LIGNANS AND PHYTOESTROGEN METABOLITES, POTENTIAL ANTIESTROGENS AND ANTICARCINOGENS, IN URINE OF WOMEN ON VARIOUS HABITUAL DIETS [J].

ADLERCREUTZ, H ;

FOTSIS, T ;

BANNWART, C ;

WAHALA, K ;

MAKELA, T ;

BRUNOW, G ;

HASE, T .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1986, 25 (5B) :791-797

[2]

ADLERCREUTZ H, 1994, CANCER DETECT PREV, V18, P259

[3] ISOTOPE-DILUTION GAS-CHROMATOGRAPHIC MASS-SPECTROMETRIC METHOD FOR THE DETERMINATION OF LIGNANS AND ISOFLAVONOIDS IN HUMAN URINE, INCLUDING IDENTIFICATION OF GENISTEIN [J].

ADLERCREUTZ, H ;

FOTSIS, T ;

BANNWART, C ;

WAHALA, K ;

BRUNOW, G ;

HASE, T .

CLINICA CHIMICA ACTA, 1991, 199 (03) :263-278

[4] ISOTOPE-DILUTION GAS-CHROMATOGRAPHIC MASS-SPECTROMETRIC METHOD FOR THE DETERMINATION OF UNCONJUGATED LIGNANS AND ISOFLAVONOIDS IN HUMAN FECES, WITH PRELIMINARY-RESULTS IN OMNIVOROUS AND VEGETARIAN WOMEN [J].

ADLERCREUTZ, H ;

FOTSIS, T ;

KURZER, MS ;

WAHALA, K ;

MAKELA, T ;

HASE, T .

ANALYTICAL BIOCHEMISTRY, 1995, 225 (01) :101-108

[5] ISOFLAVONOID BIOSYNTHESIS - CONCERNING THE ARYL MIGRATION [J].

ALANI, HAM ;

DEWICK, PM .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1984, (12) :2831-2838

[6]

ALMAHARIK N, 1999, MOL ONLINE, V3, P20

[7] STUDIES ON DRUG-METABOLISM BY USE OF ISOTOPES .26. DETERMINATION OF URINARY METABOLITES OF RUTIN IN HUMANS [J].

BABA, S ;

FURUTA, T ;

HORIE, M ;

NAKAGAWA, H .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1981, 70 (07) :780-782

[8] STUDIES ON DRUG-METABOLISM BY USE OF ISOTOPES .27. URINARY METABOLITES OF RUTIN IN RATS AND THE ROLE OF INTESTINAL MICROFLORA IN THE METABOLISM OF RUTIN [J].

BABA, S ;

FURUTA, T ;

FUJIOKA, M ;

GOROMARU, T .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1983, 72 (10) :1155-1158

[9]

Barnes S, 1998, P SOC EXP BIOL MED, V217, P254

[10]

Biemann K., 1962, Mass Spectrometry-Organic Chemical Applications, P204

← 1 2 3 4 5 6 7 →