Core-binding factors in haematopoiesis and leukaemia

被引：436

作者：

Speck, NA ^{[1
]}

Gilliland, DG

机构：

[1] Dartmouth Coll Sch Med, Dept Biochem, Hanover, NH 03755 USA

[2] Harvard Univ, Sch Med, Brigham & Womens Hosp, Howard Hughes Med Inst, Boston, MA 02115 USA

来源：

NATURE REVIEWS CANCER | 2002年 / 2卷 / 07期

关键词：

D O I：

10.1038/nrc840

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Core-binding factors (CBFs) are a class of haematopoietic transcription factors that are crucial for the regulation of haematopoietic ontogeny, and are frequent targets of mutation and gene rearrangement in human leukaemia. So, what are the functions of CBFs during development, and what are the functional consequences of CBF mutations in leukaemia? Synergy between these convergent lines of enquiry has furthered our understanding of both normal and malignant haematopoiesis.

引用

页码：502 / 513

页数：12

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