Enhancing Cancer Vaccine Efficacy via Modulation of the Tumor Microenvironment

被引：16

作者：

Disis, Mary L. ^{[1
]}

机构：

[1] Univ Washington, Ctr Translat Med Womens Hlth, Tumor Vaccine Grp, Seattle, WA 98195 USA

来源：

CLINICAL CANCER RESEARCH | 2009年 / 15卷 / 21期

关键词：

CD8(+) T-CELLS; TGF-BETA; TH17; CELLS; MELANOMA;

D O I：

10.1158/1078-0432.CCR-09-2256

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The development of therapeutic cancer vaccines is impacted by immunosuppressive elements in the tumor microenvironment. Most immunogenic cancer proteins are "self," therefore, peripheral tolerance contributes substantially to tumor immune escape. Transforming growth factor beta (TGF beta) actively modulates both inflammation and tolerance induction. Combining vaccination with agents that disarm TGF beta will enhance vaccine efficacy. (Clin Cancer Res 2009;15(21):6476-8)

引用

收藏

页码：6476 / 6478

页数：3

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