Over-Expression of EphA2 and EphrinA-1 in Human Gastric Adenocarcinoma and Its Prognostic Value for Postoperative Patients

被引：64

作者：

Yuan, Wei-Jie ^{[1
]}

Ge, Jie ^{[1
]}

Chen, Zhi-Kang ^{[1
]}

Wu, Shao-Bin ^{[1
]}

Shen, Hong ^{[2
]}

Yang, Pu ^{[3
]}

Hu, Bin ^{[1
]}

Zhang, Ge-Wen ^{[1
]}

Chen, Zi-Hua ^{[1
]}

机构：

[1] Cent S Univ, Dept Gen Surg, Xiangya Hosp, Changsha 410008, Hunan, Peoples R China

[2] Cent S Univ, Med Res Ctr, Xiangya Hosp, Changsha 410008, Hunan, Peoples R China

[3] Cent S Univ, Hepatobiliary & Enter Surg Res Ctr, Changsha 410008, Hunan, Peoples R China

来源：

DIGESTIVE DISEASES AND SCIENCES | 2009年 / 54卷 / 11期

关键词：

EphA2; EphrinA-1; Gastric adenocarcinoma; Prognosis; RECEPTOR TYROSINE KINASE; PREDICTIVE-VALUE; OVARIAN-CANCER; CARCINOMA; OVEREXPRESSION; GENE; TUMORIGENESIS; PROGRESSION; SURVIVAL; SYSTEM;

D O I：

10.1007/s10620-008-0649-4

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

This study aims to investigate the expression and significance of EphA2 and EphrinA-1 in human gastric adenocarcinoma progression and prognosis. The expression of EphA2 and EphrinA-1 was detected in the cell lines and tissues of gastric adenocarcinoma. Different expression levels of EphA2 and EphrinA-1 were found in two cell lines. The expression of EphA2 and EphrinA-1 was significantly higher in gastric adenocarcinoma tissues than in normal tissues. Statistical analysis showed a significant correlation of EphA2 expression with the depth of tumor invasion, tumor-node-metastasis (TNM) stages, and lymph node metastasis. EphrinA-1 over-expression was significantly correlated with TNM stages and lymph node metastasis, while EphA2 expression was found to be an independent prognostic factor of postoperative gastric adenocarcinoma. In conclusion, the increased expression of EphA2 and EphrinA-1 plays an important role in the progression of human gastric adenocarcinoma, in which elevated EphA2 expression is an independent factor that indicates poor prognosis in postoperative gastric adenocarcinoma.

引用

页码：2410 / 2417

页数：8

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