共 55 条
Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon
被引:318
作者:

Cervantes-Barragan, Luisa
论文数: 0 引用数: 0
h-index: 0
机构: Kantonsspital, Res Dept, CH-9007 St Gallen, Switzerland

Zuest, Roland
论文数: 0 引用数: 0
h-index: 0
机构: Kantonsspital, Res Dept, CH-9007 St Gallen, Switzerland

Weber, Friedernann
论文数: 0 引用数: 0
h-index: 0
机构: Kantonsspital, Res Dept, CH-9007 St Gallen, Switzerland

Spiegel, Martin
论文数: 0 引用数: 0
h-index: 0
机构: Kantonsspital, Res Dept, CH-9007 St Gallen, Switzerland

Lang, Karl S.
论文数: 0 引用数: 0
h-index: 0
机构: Kantonsspital, Res Dept, CH-9007 St Gallen, Switzerland

Akira, Shizuo
论文数: 0 引用数: 0
h-index: 0
机构: Kantonsspital, Res Dept, CH-9007 St Gallen, Switzerland

Thiel, Volker
论文数: 0 引用数: 0
h-index: 0
机构:
Kantonsspital, Res Dept, CH-9007 St Gallen, Switzerland Kantonsspital, Res Dept, CH-9007 St Gallen, Switzerland

论文数: 引用数:
h-index:
机构:
机构:
[1] Kantonsspital, Res Dept, CH-9007 St Gallen, Switzerland
[2] Hosp Especialidades Ctr Med La Raza, Unidad Invest Med Inmunoquim, Mexico City, DF, Mexico
[3] Univ Freiburg, Inst Med Microbiol & Hyg, Abt Virol, D-7800 Freiburg, Germany
[4] Univ Zurich Hosp, Inst Expt Immunol, CH-8091 Zurich, Switzerland
[5] Osaka Univ, Dept Host Def, Suita, Osaka 565, Japan
来源:
关键词:
D O I:
10.1182/blood-2006-05-023770
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
This study demonstrates a unique and crucial role of plasmacytold dendritic cells (pDCs) and pDC-derived type I interferons (IFNs) in the pathogenesis of mouse coronavirus infection. pDCs controlled the fast replicating mouse hepatitis virus (MHV) through the immediate production of type I IFNs. Recognition of MHV by pDCs was mediated via TLR7 ensuring a swift IFN-alpha production following encounter with this cytopathic RNA virus. Furthermore, the particular type I IFN response pattern was not restricted to the murine coronavirus, but was also found in infection with the highly cytopathic human severe acute respiratory syndrome (SARS) coronavirus. Taken together, our results suggest that rapid production of type I IFNs by pDCs is essential for the control of potentially lethal coronavirus infections.
引用
收藏
页码:1131 / 1137
页数:7
相关论文
共 55 条
- [1] Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function[J]. IMMUNITY, 1998, 9 (01) : 143 - 150Adachi, O论文数: 0 引用数: 0 h-index: 0机构: Hyogo Coll Med, Dept Biochem, Nishinomiya, Hyogo 6638501, JapanKawai, T论文数: 0 引用数: 0 h-index: 0机构: Hyogo Coll Med, Dept Biochem, Nishinomiya, Hyogo 6638501, JapanTakeda, K论文数: 0 引用数: 0 h-index: 0机构: Hyogo Coll Med, Dept Biochem, Nishinomiya, Hyogo 6638501, JapanMatsumoto, M论文数: 0 引用数: 0 h-index: 0机构: Hyogo Coll Med, Dept Biochem, Nishinomiya, Hyogo 6638501, JapanTsutsui, H论文数: 0 引用数: 0 h-index: 0机构: Hyogo Coll Med, Dept Biochem, Nishinomiya, Hyogo 6638501, JapanSakagami, M论文数: 0 引用数: 0 h-index: 0机构: Hyogo Coll Med, Dept Biochem, Nishinomiya, Hyogo 6638501, JapanNakanishi, K论文数: 0 引用数: 0 h-index: 0机构: Hyogo Coll Med, Dept Biochem, Nishinomiya, Hyogo 6638501, JapanAkira, S论文数: 0 引用数: 0 h-index: 0机构: Hyogo Coll Med, Dept Biochem, Nishinomiya, Hyogo 6638501, Japan
- [2] Toll-like receptor (TLR)-3, but not TLR4, agonist protects against genital herpes infection in the absence of inflammation seen with CpG DNA[J]. JOURNAL OF INFECTIOUS DISEASES, 2004, 190 (10) : 1841 - 1849Ashkar, AA论文数: 0 引用数: 0 h-index: 0机构: McMaster Univ, Hlth Sci Ctr, Dept Pathol & Mol Med, Ctr Gene Therapeut, Hamilton, ON L8N 3Z5, Canada McMaster Univ, Hlth Sci Ctr, Dept Pathol & Mol Med, Ctr Gene Therapeut, Hamilton, ON L8N 3Z5, CanadaYao, XD论文数: 0 引用数: 0 h-index: 0机构: McMaster Univ, Hlth Sci Ctr, Dept Pathol & Mol Med, Ctr Gene Therapeut, Hamilton, ON L8N 3Z5, Canada McMaster Univ, Hlth Sci Ctr, Dept Pathol & Mol Med, Ctr Gene Therapeut, Hamilton, ON L8N 3Z5, CanadaGill, N论文数: 0 引用数: 0 h-index: 0机构: McMaster Univ, Hlth Sci Ctr, Dept Pathol & Mol Med, Ctr Gene Therapeut, Hamilton, ON L8N 3Z5, Canada McMaster Univ, Hlth Sci Ctr, Dept Pathol & Mol Med, Ctr Gene Therapeut, Hamilton, ON L8N 3Z5, CanadaSajic, D论文数: 0 引用数: 0 h-index: 0机构: McMaster Univ, Hlth Sci Ctr, Dept Pathol & Mol Med, Ctr Gene Therapeut, Hamilton, ON L8N 3Z5, Canada McMaster Univ, Hlth Sci Ctr, Dept Pathol & Mol Med, Ctr Gene Therapeut, Hamilton, ON L8N 3Z5, CanadaPatrick, AJ论文数: 0 引用数: 0 h-index: 0机构: McMaster Univ, Hlth Sci Ctr, Dept Pathol & Mol Med, Ctr Gene Therapeut, Hamilton, ON L8N 3Z5, Canada McMaster Univ, Hlth Sci Ctr, Dept Pathol & Mol Med, Ctr Gene Therapeut, Hamilton, ON L8N 3Z5, CanadaRosenthal, KL论文数: 0 引用数: 0 h-index: 0机构: McMaster Univ, Hlth Sci Ctr, Dept Pathol & Mol Med, Ctr Gene Therapeut, Hamilton, ON L8N 3Z5, Canada McMaster Univ, Hlth Sci Ctr, Dept Pathol & Mol Med, Ctr Gene Therapeut, Hamilton, ON L8N 3Z5, CanadaRosenthal, L论文数: 0 引用数: 0 h-index: 0机构: McMaster Univ, Hlth Sci Ctr, Dept Pathol & Mol Med, Ctr Gene Therapeut, Hamilton, ON L8N 3Z5, Canada McMaster Univ, Hlth Sci Ctr, Dept Pathol & Mol Med, Ctr Gene Therapeut, Hamilton, ON L8N 3Z5, Canada
- [3] Mouse type IIFN-producing cells are immature APCs with plasmacytoid morphology[J]. NATURE IMMUNOLOGY, 2001, 2 (12) : 1144 - 1150Asselin-Paturel, C论文数: 0 引用数: 0 h-index: 0机构: Schering Plough Corp, Lab Immunol Res, Dardilly, FranceBoonstra, A论文数: 0 引用数: 0 h-index: 0机构: Schering Plough Corp, Lab Immunol Res, Dardilly, France论文数: 引用数: h-index:机构:Durand, I论文数: 0 引用数: 0 h-index: 0机构: Schering Plough Corp, Lab Immunol Res, Dardilly, FranceYessaad, N论文数: 0 引用数: 0 h-index: 0机构: Schering Plough Corp, Lab Immunol Res, Dardilly, FranceDezutter-Dambuyant, C论文数: 0 引用数: 0 h-index: 0机构: Schering Plough Corp, Lab Immunol Res, Dardilly, FranceVicari, A论文数: 0 引用数: 0 h-index: 0机构: Schering Plough Corp, Lab Immunol Res, Dardilly, FranceO'Garra, A论文数: 0 引用数: 0 h-index: 0机构: Schering Plough Corp, Lab Immunol Res, Dardilly, FranceBiron, C论文数: 0 引用数: 0 h-index: 0机构: Schering Plough Corp, Lab Immunol Res, Dardilly, FranceBrière, F论文数: 0 引用数: 0 h-index: 0机构: Schering Plough Corp, Lab Immunol Res, Dardilly, FranceTrinchieri, G论文数: 0 引用数: 0 h-index: 0机构: Schering Plough Corp, Lab Immunol Res, Dardilly, France Schering Plough Corp, Lab Immunol Res, Dardilly, France
- [4] Virus-induced interferon α production by a dendritic cell subset in the absence of feedback signaling in vivo[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (04) : 507 - 516论文数: 引用数: h-index:机构:Cella, M论文数: 0 引用数: 0 h-index: 0机构: EMBL, Mouse Biol Programme, I-00016 Monterotondo, ItalyOdermatt, B论文数: 0 引用数: 0 h-index: 0机构: EMBL, Mouse Biol Programme, I-00016 Monterotondo, ItalyAsselin-Paturel, C论文数: 0 引用数: 0 h-index: 0机构: EMBL, Mouse Biol Programme, I-00016 Monterotondo, ItalyColonna, M论文数: 0 引用数: 0 h-index: 0机构: EMBL, Mouse Biol Programme, I-00016 Monterotondo, ItalyKalinke, U论文数: 0 引用数: 0 h-index: 0机构: EMBL, Mouse Biol Programme, I-00016 Monterotondo, Italy
- [5] Coronavirus infection of the central nervous system: host-virus stand-off[J]. NATURE REVIEWS MICROBIOLOGY, 2006, 4 (02) : 121 - 132Bergmann, CC论文数: 0 引用数: 0 h-index: 0机构: Cleveland Clin Fdn, Cleveland, OH 44195 USALane, TE论文数: 0 引用数: 0 h-index: 0机构: Cleveland Clin Fdn, Cleveland, OH 44195 USAStohlman, SA论文数: 0 引用数: 0 h-index: 0机构: Cleveland Clin Fdn, Cleveland, OH 44195 USA
- [6] Perforin and gamma interferon-mediated control of coronavirus central nervous system infection by CD8 T cells in the absence of CD4 T cells[J]. JOURNAL OF VIROLOGY, 2004, 78 (04) : 1739 - 1750Bergmann, CC论文数: 0 引用数: 0 h-index: 0机构: Univ So Calif, Keck Sch Med, Dept Neurol, Los Angeles, CA 90033 USAParra, B论文数: 0 引用数: 0 h-index: 0机构: Univ So Calif, Keck Sch Med, Dept Neurol, Los Angeles, CA 90033 USAHinton, DR论文数: 0 引用数: 0 h-index: 0机构: Univ So Calif, Keck Sch Med, Dept Neurol, Los Angeles, CA 90033 USARamakrishna, C论文数: 0 引用数: 0 h-index: 0机构: Univ So Calif, Keck Sch Med, Dept Neurol, Los Angeles, CA 90033 USADowdell, KC论文数: 0 引用数: 0 h-index: 0机构: Univ So Calif, Keck Sch Med, Dept Neurol, Los Angeles, CA 90033 USAStohlman, SA论文数: 0 引用数: 0 h-index: 0机构: Univ So Calif, Keck Sch Med, Dept Neurol, Los Angeles, CA 90033 USA
- [7] Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon[J]. NATURE MEDICINE, 1999, 5 (08) : 919 - 923Cella, M论文数: 0 引用数: 0 h-index: 0机构: Beckman Coulter Co, Basel Inst Immunol, Marseille, FranceJarrossay, D论文数: 0 引用数: 0 h-index: 0机构: Beckman Coulter Co, Basel Inst Immunol, Marseille, France论文数: 引用数: h-index:机构:Alebardi, O论文数: 0 引用数: 0 h-index: 0机构: Beckman Coulter Co, Basel Inst Immunol, Marseille, FranceNakajima, H论文数: 0 引用数: 0 h-index: 0机构: Beckman Coulter Co, Basel Inst Immunol, Marseille, FranceLanzavecchia, A论文数: 0 引用数: 0 h-index: 0机构: Beckman Coulter Co, Basel Inst Immunol, Marseille, FranceColonna, M论文数: 0 引用数: 0 h-index: 0机构: Beckman Coulter Co, Basel Inst Immunol, Marseille, France Beckman Coulter Co, Basel Inst Immunol, Marseille, France
- [8] Cytokine responses in severe acute respiratory syndrome coronavirus-infected macrophages in vitro: possible relevance to pathogenesis[J]. JOURNAL OF VIROLOGY, 2005, 79 (12) : 7819 - 7826Cheung, CY论文数: 0 引用数: 0 h-index: 0机构: Univ Hong Kong, Queen Mary Hosp, Dept Microbiol, Hong Kong, Hong Kong, Peoples R ChinaPoon, LLM论文数: 0 引用数: 0 h-index: 0机构: Univ Hong Kong, Queen Mary Hosp, Dept Microbiol, Hong Kong, Hong Kong, Peoples R ChinaNg, IHY论文数: 0 引用数: 0 h-index: 0机构: Univ Hong Kong, Queen Mary Hosp, Dept Microbiol, Hong Kong, Hong Kong, Peoples R ChinaLuk, W论文数: 0 引用数: 0 h-index: 0机构: Univ Hong Kong, Queen Mary Hosp, Dept Microbiol, Hong Kong, Hong Kong, Peoples R ChinaSia, SF论文数: 0 引用数: 0 h-index: 0机构: Univ Hong Kong, Queen Mary Hosp, Dept Microbiol, Hong Kong, Hong Kong, Peoples R ChinaWu, MHS论文数: 0 引用数: 0 h-index: 0机构: Univ Hong Kong, Queen Mary Hosp, Dept Microbiol, Hong Kong, Hong Kong, Peoples R ChinaChan, KH论文数: 0 引用数: 0 h-index: 0机构: Univ Hong Kong, Queen Mary Hosp, Dept Microbiol, Hong Kong, Hong Kong, Peoples R ChinaYuen, KY论文数: 0 引用数: 0 h-index: 0机构: Univ Hong Kong, Queen Mary Hosp, Dept Microbiol, Hong Kong, Hong Kong, Peoples R ChinaGordon, S论文数: 0 引用数: 0 h-index: 0机构: Univ Hong Kong, Queen Mary Hosp, Dept Microbiol, Hong Kong, Hong Kong, Peoples R ChinaGuan, Y论文数: 0 引用数: 0 h-index: 0机构: Univ Hong Kong, Queen Mary Hosp, Dept Microbiol, Hong Kong, Hong Kong, Peoples R ChinaPeiris, JSM论文数: 0 引用数: 0 h-index: 0机构: Univ Hong Kong, Queen Mary Hosp, Dept Microbiol, Hong Kong, Hong Kong, Peoples R China
- [9] Treatment of SARS with human interferons[J]. LANCET, 2003, 362 (9380) : 293 - 294Cinatl, J论文数: 0 引用数: 0 h-index: 0机构: Univ Frankfurt, Sch Med, Inst Med Virol, D-60596 Frankfurt, Germany Univ Frankfurt, Sch Med, Inst Med Virol, D-60596 Frankfurt, GermanyMorgenstern, B论文数: 0 引用数: 0 h-index: 0机构: Univ Frankfurt, Sch Med, Inst Med Virol, D-60596 Frankfurt, Germany Univ Frankfurt, Sch Med, Inst Med Virol, D-60596 Frankfurt, GermanyBauer, G论文数: 0 引用数: 0 h-index: 0机构: Univ Frankfurt, Sch Med, Inst Med Virol, D-60596 Frankfurt, Germany Univ Frankfurt, Sch Med, Inst Med Virol, D-60596 Frankfurt, GermanyChandra, P论文数: 0 引用数: 0 h-index: 0机构: Univ Frankfurt, Sch Med, Inst Med Virol, D-60596 Frankfurt, Germany Univ Frankfurt, Sch Med, Inst Med Virol, D-60596 Frankfurt, GermanyRabenau, H论文数: 0 引用数: 0 h-index: 0机构: Univ Frankfurt, Sch Med, Inst Med Virol, D-60596 Frankfurt, Germany Univ Frankfurt, Sch Med, Inst Med Virol, D-60596 Frankfurt, GermanyDoerr, HW论文数: 0 引用数: 0 h-index: 0机构: Univ Frankfurt, Sch Med, Inst Med Virol, D-60596 Frankfurt, Germany Univ Frankfurt, Sch Med, Inst Med Virol, D-60596 Frankfurt, Germany
- [10] Role of interferons in the treatment of severe acute respiratory syndrome[J]. EXPERT OPINION ON BIOLOGICAL THERAPY, 2004, 4 (06) : 827 - 836Cinatl, J论文数: 0 引用数: 0 h-index: 0机构: Univ Frankfurt Klinikum, Inst Med Virol, D-60596 Frankfurt, Germany Univ Frankfurt Klinikum, Inst Med Virol, D-60596 Frankfurt, GermanyMichaelis, M论文数: 0 引用数: 0 h-index: 0机构: Univ Frankfurt Klinikum, Inst Med Virol, D-60596 Frankfurt, Germany Univ Frankfurt Klinikum, Inst Med Virol, D-60596 Frankfurt, GermanyScholz, M论文数: 0 引用数: 0 h-index: 0机构: Univ Frankfurt Klinikum, Inst Med Virol, D-60596 Frankfurt, Germany Univ Frankfurt Klinikum, Inst Med Virol, D-60596 Frankfurt, GermanyDoerr, HW论文数: 0 引用数: 0 h-index: 0机构: Univ Frankfurt Klinikum, Inst Med Virol, D-60596 Frankfurt, Germany Univ Frankfurt Klinikum, Inst Med Virol, D-60596 Frankfurt, Germany