Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon

被引:318
作者
Cervantes-Barragan, Luisa
Zuest, Roland
Weber, Friedernann
Spiegel, Martin
Lang, Karl S.
Akira, Shizuo
Thiel, Volker [1 ]
Ludewig, Burkhard
机构
[1] Kantonsspital, Res Dept, CH-9007 St Gallen, Switzerland
[2] Hosp Especialidades Ctr Med La Raza, Unidad Invest Med Inmunoquim, Mexico City, DF, Mexico
[3] Univ Freiburg, Inst Med Microbiol & Hyg, Abt Virol, D-7800 Freiburg, Germany
[4] Univ Zurich Hosp, Inst Expt Immunol, CH-8091 Zurich, Switzerland
[5] Osaka Univ, Dept Host Def, Suita, Osaka 565, Japan
关键词
D O I
10.1182/blood-2006-05-023770
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
This study demonstrates a unique and crucial role of plasmacytold dendritic cells (pDCs) and pDC-derived type I interferons (IFNs) in the pathogenesis of mouse coronavirus infection. pDCs controlled the fast replicating mouse hepatitis virus (MHV) through the immediate production of type I IFNs. Recognition of MHV by pDCs was mediated via TLR7 ensuring a swift IFN-alpha production following encounter with this cytopathic RNA virus. Furthermore, the particular type I IFN response pattern was not restricted to the murine coronavirus, but was also found in infection with the highly cytopathic human severe acute respiratory syndrome (SARS) coronavirus. Taken together, our results suggest that rapid production of type I IFNs by pDCs is essential for the control of potentially lethal coronavirus infections.
引用
收藏
页码:1131 / 1137
页数:7
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共 55 条
  • [1] Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function
    Adachi, O
    Kawai, T
    Takeda, K
    Matsumoto, M
    Tsutsui, H
    Sakagami, M
    Nakanishi, K
    Akira, S
    [J]. IMMUNITY, 1998, 9 (01) : 143 - 150
  • [2] Toll-like receptor (TLR)-3, but not TLR4, agonist protects against genital herpes infection in the absence of inflammation seen with CpG DNA
    Ashkar, AA
    Yao, XD
    Gill, N
    Sajic, D
    Patrick, AJ
    Rosenthal, KL
    Rosenthal, L
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2004, 190 (10) : 1841 - 1849
  • [3] Mouse type IIFN-producing cells are immature APCs with plasmacytoid morphology
    Asselin-Paturel, C
    Boonstra, A
    Dalod, M
    Durand, I
    Yessaad, N
    Dezutter-Dambuyant, C
    Vicari, A
    O'Garra, A
    Biron, C
    Brière, F
    Trinchieri, G
    [J]. NATURE IMMUNOLOGY, 2001, 2 (12) : 1144 - 1150
  • [4] Virus-induced interferon α production by a dendritic cell subset in the absence of feedback signaling in vivo
    Barchet, W
    Cella, M
    Odermatt, B
    Asselin-Paturel, C
    Colonna, M
    Kalinke, U
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (04) : 507 - 516
  • [5] Coronavirus infection of the central nervous system: host-virus stand-off
    Bergmann, CC
    Lane, TE
    Stohlman, SA
    [J]. NATURE REVIEWS MICROBIOLOGY, 2006, 4 (02) : 121 - 132
  • [6] Perforin and gamma interferon-mediated control of coronavirus central nervous system infection by CD8 T cells in the absence of CD4 T cells
    Bergmann, CC
    Parra, B
    Hinton, DR
    Ramakrishna, C
    Dowdell, KC
    Stohlman, SA
    [J]. JOURNAL OF VIROLOGY, 2004, 78 (04) : 1739 - 1750
  • [7] Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon
    Cella, M
    Jarrossay, D
    Facchetti, F
    Alebardi, O
    Nakajima, H
    Lanzavecchia, A
    Colonna, M
    [J]. NATURE MEDICINE, 1999, 5 (08) : 919 - 923
  • [8] Cytokine responses in severe acute respiratory syndrome coronavirus-infected macrophages in vitro: possible relevance to pathogenesis
    Cheung, CY
    Poon, LLM
    Ng, IHY
    Luk, W
    Sia, SF
    Wu, MHS
    Chan, KH
    Yuen, KY
    Gordon, S
    Guan, Y
    Peiris, JSM
    [J]. JOURNAL OF VIROLOGY, 2005, 79 (12) : 7819 - 7826
  • [9] Treatment of SARS with human interferons
    Cinatl, J
    Morgenstern, B
    Bauer, G
    Chandra, P
    Rabenau, H
    Doerr, HW
    [J]. LANCET, 2003, 362 (9380) : 293 - 294
  • [10] Role of interferons in the treatment of severe acute respiratory syndrome
    Cinatl, J
    Michaelis, M
    Scholz, M
    Doerr, HW
    [J]. EXPERT OPINION ON BIOLOGICAL THERAPY, 2004, 4 (06) : 827 - 836