Pamidronate infusion in patients with systemic sclerosis results in changes in blood mononuclear cell cytokine profiles

被引：18

作者：

Carbone, L. D.

Warrington, K. J.

Barrow, K. D.

Pugazhenthi, M.

Watsky, M. A.

Somes, G.

Ingels, J.

Postlethwaite, A. E.

机构：

[1] Univ Tennessee, Vet Affairs Med Ctr, Div Connect Tissue Dis, Memphis, TN 38163 USA

[2] Univ Tennessee, Div Pulm Med, Dept Med, Memphis, TN 38163 USA

[3] Univ Tennessee, Dept Prevent Med, Memphis, TN 38163 USA

[4] Univ Tennessee, Dept Physiol, Memphis, TN 38163 USA

来源：

CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 2006年 / 146卷 / 03期

关键词：

cytokines; lymphocytes; pamidronate; scleroderma; systemic sclerosis;

D O I：

10.1111/j.1365-2249.2006.03216.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A single infusion of pamidronate was given to patients with systemic sclerosis (scleroderma, SSc) to assess effects on cytokine production by peripheral blood mononuclear cells (PBMC) and lymphocyte subsets. Eighteen patients with SSc received a single intravenous dose of 60 mg of pamidronate and were followed for 6 months. Assessment of cytokine production [interferon (IFN)-gamma, interleukin (IL)-10, transforming growth factor (TGF)-beta 1, tumour necrosis factor (TNF)-alpha and IL-4] by PBMC and lymphocyte subsets by flow cytometry was carried out before and after the pamidronate infusion. Unstimulated PBMC produced increased amounts of IFN-gamma and TNF-alpha and reduced levels of TGF-beta 1 for up to 24 weeks after the infusion. gamma delta T cells from patients with SSc were activated in vitro and produced increased IFN-gamma. The effects of pamidronate on modulation of cytokine profiles in patients with SSc may merit future study.

引用

页码：371 / 380

页数：10

共 57 条

[1] Tumor necrosis factor α suppresses the induction of connective tissue growth factor by transforming growth factor-β in normal and scleroderma fibroblasts [J].