In-process ATR-FTIR spectroscopy for closed-loop supersaturation control of a batch crystallizer producing monosodium glutamate crystals of defined size

被引:115
作者
Grön, H
Borissova, A
Roberts, KJ [1 ]
机构
[1] Univ Leeds, Dept Chem Engn, Inst Particle Sci & Engn, Leeds LS2 9JT, W Yorkshire, England
[2] Heriot Watt Univ, Res Sch Phys Sci & Engn, Ctr Mol & Interface Engn, Edinburgh EH14 4AS, Midlothian, Scotland
关键词
D O I
10.1021/ie020346d
中图分类号
TQ [化学工业];
学科分类号
0817 ;
摘要
Closed-loop computer control of solution supersaturation based on in-process measurements of the concentration using ATR-FTIR spectroscopy and adaptive determination of the corresponding temperature profile has been applied to control the crystallization of monosodium glutamate from an aqueous solution. The crystal size and its distribution are varied and optimized by applying different control strategies such as rapid desupersaturation, constant supersaturation, and step-changing supersaturation profiles.
引用
收藏
页码:198 / 206
页数:9
相关论文
共 24 条
[1]   On-line analytical techniques for monitoring crystallisation processes of organic speciality chemicals [J].
Baker, M ;
Cao, ZY ;
Dale, D ;
Erk, P ;
Ford, L ;
Groen, H ;
Latham, D ;
Hammond, RB ;
Lai, XJ ;
Liang, KP ;
Merrifield, D ;
Mougin, P ;
Oliver, R ;
Roberts, D ;
Roberts, KJ ;
Savelli, N ;
Thomas, A ;
White, G ;
Wilkinson, D ;
Wood, W .
MOLECULAR CRYSTALS AND LIQUID CRYSTALS, 2001, 356 :273-287
[2]  
BORISSOVA A, 2002, CHEM ENG T, V3
[3]  
CAO Z, 1999, P 5 INT WORKSH CRYST
[4]   Effect of cooling mode on product crystal size in seeded batch crystallization of potassium alum [J].
Doki, N ;
Kubota, N ;
Sato, A ;
Yokota, M .
CHEMICAL ENGINEERING JOURNAL, 2001, 81 (1-3) :313-316
[5]   ATR FTIR spectroscopy for in situ measurement of supersaturation [J].
Dunuwila, DD ;
Berglund, KA .
JOURNAL OF CRYSTAL GROWTH, 1997, 179 (1-2) :185-193
[6]   ATR-FTIR for determining optimal cooling curves for batch crystallization of succinic acid [J].
Feng, LL ;
Berglund, KA .
CRYSTAL GROWTH & DESIGN, 2002, 2 (05) :449-452
[7]   Paracetamol crystallization using laser backscattering and ATR-FTIR spectroscopy: Metastability, agglomeration, and control [J].
Fujiwara, M ;
Chow, PS ;
Ma, DL ;
Braatz, RD .
CRYSTAL GROWTH & DESIGN, 2002, 2 (05) :363-370
[8]   Nucleation, growth, and pseudo-polymorphic behavior of citric acid as monitored in situ by attenuated total reflection Fourier transform infrared spectroscopy [J].
Groen, H ;
Roberts, KJ .
JOURNAL OF PHYSICAL CHEMISTRY B, 2001, 105 (43) :10723-10730
[9]  
GROEN H, 1999, P 5 INT WORKSH CRYST
[10]  
GROEN H, 1999, SPECIAL PUBLICATION, V236, P40