Prognostic value of loss of heterozygosity at BRCA2 in human breast carcinoma

被引：14

作者：

Bieche, I

Nogues, C

Rivoilan, S

Khodja, A

Latil, A

Lidereau, R

机构：

[1] CTR RENE HUGUENIN, LAB ONCOGENET, F-92211 ST CLOUD, FRANCE

[2] CTR RENE HUGUENIN, DEPT MED STAT, F-92211 ST CLOUD, FRANCE

来源：

BRITISH JOURNAL OF CANCER | 1997年 / 76卷 / 11期

关键词：

BRCA2; loss of heterozygosity; prognostic value; breast cancer;

D O I：

10.1038/bjc.1997.572

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To confirm several recent studies pointing to loss of heterozygosity (LOH) at BRCA2 as a prognostic factor in sporadic breast cancer, we examined this genetic alteration in a large series of human primary breast tumours for which long-term patient outcomes were known. LOH at BRCA2 correlated only with low oestrogen and progesterone receptor content. Univariate analysis of metastasis-free survival and overall survival (log-rank test) showed no link with BRCA2 status (P = 0.34, P = 0.29 respectively). LOH at BRCA2 does not therefore appear to be a major prognostic marker in sporadic breast cancer.

引用

页码：1416 / 1418

页数：3

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