CXCL8 and its cognate receptors in melanoma progression and metastasis

被引：84

作者：

Singh, Seema ^{[2
]}

Singh, Ajay P. ^{[2
]}

Sharma, Bhawna ^{[1
]}

Owen, Laurie B. ^{[2
]}

Singh, Rakesh K. ^{[1
]}

机构：

[1] Univ Nebraska Med Ctr, Dept Pathol & Microbiol, Omaha, NE 68198 USA

[2] Univ S Alabama, Mitchell Canc Inst, Dept Oncol Sci, Mobile, AL 36688 USA

来源：

FUTURE ONCOLOGY | 2010年 / 6卷 / 01期

关键词：

CXCL8; CXCR1; CXCR2; melanoma; MICROVASCULAR ENDOTHELIAL-CELLS; NF-KAPPA-B; MALIGNANT-MELANOMA; MATRIX METALLOPROTEINASES; IN-VITRO; INTERLEUKIN-8; EXPRESSION; TUMOR-GROWTH; CXCR2; ANGIOGENESIS; CHEMOKINES;

D O I：

10.2217/FON.09.128

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The incidence of melanoma is rising at an alarming rate and we are still awaiting an effective treatment for this malignancy. In its early stage, melanoma can be cured by surgical removal, but once metastasis has occurred there is no effective treatment. Recent findings have suggested multiple functional implications of CXCL8 and its cognate receptors, CXCR1 and CXCR2, in melanoma pathogenesis, thus underscoring their importance as targets for cancer therapy. This review provides an update on the roles of CXCL8 and its receptors in melanoma progression and metastasis.

引用

页码：111 / 116

页数：6

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