Lactobacilli as live vaccine delivery vectors: progress and prospects

被引：178

作者：

Seegers, JFML ^{[1
]}

机构：

[1] TNO Prevent & Hlth, Div Immunol & Infect Dis, Leiden, Netherlands

来源：

TRENDS IN BIOTECHNOLOGY | 2002年 / 20卷 / 12期

关键词：

D O I：

10.1016/S0167-7799(02)02075-9

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Evidence is accumulating that lactobacilli influence the immune response in a strain-dependent manner. This immunomodulatory capacity is important for the development of the immune response, and also identifies Lactobacillus as a potent oral vaccine carrier. Most of our current knowledge of the use of lactobacilli for vaccination purposes has been obtained with tetanus toxin fragment C (TTFC) as the model antigen. This knowledge, together with our ever-increasing understanding of the immune system and recent developments in cloning and expression techniques, should enable the utilisation of antigens other than TTFC and has made the development of lactobacilli as live vaccines a realistic prospect.

引用

页码：508 / 515

页数：8

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