Experimental Blastocystis hominis infection in laboratory mice

被引：88

作者：

Moe, KT ^{[1
]}

Singh, M ^{[1
]}

Howe, J ^{[1
]}

Ho, LC ^{[1
]}

Tan, SW ^{[1
]}

Chen, XQ ^{[1
]}

Ng, GC ^{[1
]}

Yap, EH ^{[1
]}

机构：

[1] NATL UNIV SINGAPORE, FAC MED, DEPT MICROBIOL, SINGAPORE 119260, SINGAPORE

来源：

PARASITOLOGY RESEARCH | 1997年 / 83卷 / 04期

关键词：

D O I：

10.1007/s004360050256

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Young (less than 8 weeks old) immunocompetent BALB/c mice became infected with Blastocystis hominis after inoculation of fecal cysts orally and of in vitro axenic-culture forms intracecally. This study confirmed that the fecal cyst was the form responsible for external transmission and that the mode of transmission was by the fecal-oral route. The infection was self-limiting and the infected BALB/c mice appeared normal except that some of them showed weight loss and lethargy. Both vacuolar and granular forms were found in the cecum, but only cyst forms were observed in the colon. Histological examination of the cecum and colon showed intense inflammatory-cell infiltration, edematous lamina propria, and mucosal sloughing. It is apparent that although B. hominis is not invasive, it is capable of causing pathogenesis in BALB/c mice.

引用

页码：319 / 325

页数：7

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