Analytical considerations and plans to standardize or harmonize assays for the reference bone turnover markers PINP and β-CTX in blood

被引：40

作者：

Bhattoa, Harjit P. ^{[1
]}

Cavalier, Etienne ^{[2
]}

Eastell, Richard ^{[3
]}

Heijboer, Annemieke C. ^{[4
,5
]}

Jorgensen, Niklas R. ^{[6
,7
]}

Makris, Konstantinos ^{[8
,9
]}

Ulmer, Candice Z. ^{[10
]}

Kanis, John A. ^{[11
,12
]}

Cooper, Cyrus ^{[13
]}

Silverman, Stuart L. ^{[14
,15
]}

Vasikaran, Samuel D. ^{[16
]}

机构：

[1] Univ Debrecen, Fac Med, Dept Lab Med, Debrecen, Hungary

[2] Univ Liege, Dept Clin Chem, CHU Liege, B-4000 Liege, Belgium

[3] Univ Sheffield, Mellanby Ctr Bone Res, Sheffield, S Yorkshire, England

[4] Vrije Univ Amsterdam, Dept Clin Chem, Endocrine Lab, Amsterdam Gastroenterol & Metab, Amsterdam, Netherlands

[5] Univ Amsterdam, Amsterdam UMC, Amsterdam, Netherlands

[6] Rigshosp, Dept Clin Biochem, DK-2600 Glostrup, Denmark

[7] Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark

[8] KAT Gen Hosp, Clin Biochem Dept, Athens 14561, Greece

[9] Univ Athens, Med Sch, Lab Res Musculoskeletal Syst Th Garofalidis, Athens, Greece

[10] Ctr Dis Control & Prevent, Clin Chem Branch, Div Lab Sci, Natl Ctr Environm Hlth, Atlanta, GA USA

[11] Univ Sheffield, Ctr Metab Bone Dis, Med Sch, Sheffield, S Yorkshire, England

[12] Australian Catholic Univ, Mary McKillop Inst Hlth Res, Melbourne, Vic, Australia

[13] Univ Southampton, Southampton Gen Hosp, MRC, Epidemiol Resource Ctr, Southampton, Hants, England

[14] Cedars Sinai Med Ctr, Beverly Hills, CA USA

[15] Univ Calif Los Angeles, Sch Med, Beverly Hills, CA USA

[16] Fiona Stanley Hosp, PathWest Lab Med, Murdoch, WA, Australia

来源：

CLINICA CHIMICA ACTA | 2021年 / 515卷

基金：

英国医学研究理事会;

关键词：

Procollagen type I N-propeptide; PINP; C-terminal telopeptide of type I collagen; beta-CTX; Bone turnover markers; Bone formation; Bone resorption; Standardization; Harmonization; N-TERMINAL PROPEPTIDE; PROCOLLAGEN TYPE-I; CROSS-LINKING TELOPEPTIDE; AUTOMATED SERUM ASSAY; DEGRADATION-PRODUCTS; REFERENCE INTERVALS; AMINOTERMINAL PROPEPTIDE; COMMERCIAL ASSAYS; COLLAGEN; FETAL;

D O I：

10.1016/j.cca.2020.12.023

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

100118 [医学信息学]; 100208 [临床检验诊断学];

摘要：

Procollagen type I N-propeptide (PINP) and the C-terminal telopeptide of type I collagen (beta-CTX) in blood have been designated as reference bone turnover markers in osteoporosis by the International Osteoporosis Foundation (IOF) and International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). The IFCC Committee on Bone Metabolism (C-BM) has examined current commercial assays and performed a multicentre study to examine the agreement between assays for PINP and beta-CTX in serum and plasma. The results of these studies will inform our work towards the harmonization of PINP assays and the standardization of beta-CTX assays in blood, with the development of common calibrators and reference measurement procedures in collaboration with the reagent manufacturing industry. Successful achievement of these goals will help develop universally acceptable practice guidelines for the management of osteoporosis with the inclusion of common reference intervals and treatment targets for PINP and beta-CTX.

引用

页码：16 / 20

页数：5

共 37 条

[1]

Measurement of bone degradation products in serum using antibodies reactive with an isomerized form of an 8 amino acid sequence of the C-telopeptide of type I collagen [J].