Protein P200 is dispensable for Mycoplasma pneumoniae hemadsorption but not gliding motility or colonization of differentiated bronchial epithelium

被引：42

作者：

Jordan, Jarrat L.

Chang, How-Yi

Balish, Mitchell F.

Holt, Lynley S.

Bose, Stephanie R.

Hasselbring, Benjamin M.

Waldo, Robert H., III

Krunkosky, Thomas M.

Krause, Duncan C.

机构：

[1] Univ Georgia, Dept Microbiol, Athens, GA 30602 USA

[2] Univ Georgia, Dept Anat & Radiol, Athens, GA 30602 USA

来源：

INFECTION AND IMMUNITY | 2007年 / 75卷 / 01期

关键词：

D O I：

10.1128/IAI.01344-06

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mycoplasma pneumoniae protein P200 was localized to the terminal organelle, which functions in cytadherence and gliding motility. The loss of P200 had no impact on binding to erythrocytes and A549 cells but resulted in impaired gliding motility and colonization of differentiated bronchial epithelium. Thus, gliding may be necessary to overcome mucociliary clearance.

引用

收藏

页码：518 / 522

页数：5

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