Effects of calcium and vitamin supplementation on colon cell proliferation in colorectal cancer

被引:27
作者
Cascinu, S [1 ]
Ligi, M
Del Ferro, E
Foglietti, G
Cioccolini, P
Staccioli, MP
Carnevali, A
Rocchi, MBL
Alessandroni, P
Giordani, P
Catalano, V
Polizzi, V
Agostinelli, R
Muretto, P
Catalano, G
机构
[1] Azienda Ospedaliera S Salvatore, Dept Hematol Oncol, Sect Expt Oncol, I-61100 Pesaro, Italy
[2] Azienda Ospedaliera S Salvatore, Sect Expt Oncol, I-61100 Pesaro, Italy
[3] Azienda Ospedaliera S Salvatore, Dept Surg, I-61100 Pesaro, Italy
[4] Azienda Ospedaliera S Salvatore, Dept Pathol, I-61100 Pesaro, Italy
[5] Univ Urbino, Inst Biomath, I-61029 Urbino, Italy
关键词
D O I
10.3109/07357900009032811
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Calcium and antioxidant vitamins, such as A, C, and E, have been shown to reduce colorectal epithelial proliferation and thereby to act as possible chemoprotective agents in colorectal cancer. We investigated the effects of an intervention with calcium and vitamins on cell proliferation in the colonic mucosa of patients operated on for colorectal cancer Patients with resected colorectal cancer Dukes' stage BC were randomized to receive daily 30,000 IU of axerophthol palmitate (vitamin A) plus I g ascorbic acid (vitamin C) pills 70 mg of dl-alpha-tocopherol acetate (vitamin E) and 2 g natural calcium daily or indistinguishable placebo for 6 months. At the rime of surgery and after 6 and 12 months of treatment, cell kinetics of normal colonic mucosa Ir ere assessed by using proliferating cell nuclear antigen (PCNA). Ninety patients,were enrolled and 77 were assessable: 34 in the treatment group and 43 in the placebo group. A significant reduction of mean total PCNA labeling index (PCNALI) was evident in both groups after 6 months (vitamins/calcium, from 16.11 +/- 2.43 to 10.71 +/- 2.81; placebo, from 17.30 +/- 2.63 to 12.53 +/- 3.40). The difference in the percentage of reduction of mean PCNALI between baseline and after 6 months was nor statistically significant in the treatment and placebo groups: 34% and 28%, respectively. A second control, 6 months after discontinuously of vitamin and calcium supplementation, showed a further decrease of,mean total PCNALI in both groups, bur this was not statistically. significant. Our. randomized trial showed that calcium and vitamin supplementation does not reduce cell kinetics of colon epithelium. Furthermore, this study suggests the need for extreme caution in the interpretation and publication of studies on chemoprotectants in colon cancer without a control group.
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收藏
页码:411 / 416
页数:6
相关论文
共 33 条
[1]   THE EFFECT OF CALCIUM SUPPLEMENTS ON RECTAL MUCOSAL PROLIFERATION [J].
ARMITAGE, NC ;
ROONEY, PS ;
GIFFORD, KA ;
CLARKE, PA ;
HARDCASTLE, JD .
BRITISH JOURNAL OF CANCER, 1995, 71 (01) :186-190
[2]   REDUCTION OF MUCOSAL CRYPT CELL-PROLIFERATION IN PATIENTS WITH COLORECTAL ADENOMATOUS POLYPS BY DIETARY CALCIUM SUPPLEMENTATION [J].
BARSOUM, GH ;
HENDRICKSE, C ;
WINSLET, MC ;
YOUNGS, D ;
DONOVAN, IA ;
NEOPTOLEMOS, JP ;
KEIGHLEY, MRB .
BRITISH JOURNAL OF SURGERY, 1992, 79 (06) :581-583
[3]  
BARTRAM HP, 1993, CANCER RES, V53, P3283
[4]   CORRELATION BETWEEN [H-3] THYMIDINE AND PROLIFERATING CELL NUCLEAR ANTIGEN (PCNA) CYCLIN INDEXES IN ARCHIVAL, FORMALDEHYDE-FIXED HUMAN COLORECTAL TISSUES [J].
BLEIBERG, H ;
MORRET, M ;
GALAND, P .
EUROPEAN JOURNAL OF CANCER, 1993, 29A (03) :400-403
[5]   CALCIUM AND COLORECTAL EPITHELIAL-CELL PROLIFERATION - A PRELIMINARY RANDOMIZED, DOUBLE-BLINDED, PLACEBO-CONTROLLED CLINICAL-TRIAL [J].
BOSTICK, RM ;
POTTER, JD ;
FOSDICK, L ;
GRAMBSCH, P ;
LAMPE, JW ;
WOOD, JR ;
LOUIS, TA ;
GANZ, R ;
GRANDITS, G .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1993, 85 (02) :132-141
[6]  
Bromley M, 1996, EUR J HISTOCHEM, V40, P89
[7]   CIRCADIAN-RHYTHM OF CELLULAR PROLIFERATION IN THE HUMAN RECTAL MUCOSA [J].
BUCHI, KN ;
MOORE, JG ;
HRUSHESKY, WJM ;
SOTHERN, RB ;
RUBIN, NH .
GASTROENTEROLOGY, 1991, 101 (02) :410-415
[8]  
BUSET M, 1986, CANCER RES, V46, P5426
[9]   EFFECTS OF VITAMIN ANTIOXIDANT SUPPLEMENTATION ON CELL-KINETICS OF PATIENTS WITH ADENOMATOUS POLYPS [J].
CAHILL, RJ ;
OSULLIVAN, KR ;
MATHIAS, PM ;
BEATTIE, S ;
HAMILTON, H ;
OMORAIN, C .
GUT, 1993, 34 (07) :963-967
[10]  
CASCINU S, 1994, ONCOL REP, V1, P1229