Using decomposed household food acquisitions as inputs of a Kinetic Dietary Exposure Model

被引:5
作者
Allais, Olivier [1 ]
Tressou, Jessica [2 ]
机构
[1] INRA CORELA, Lab Rech Consommat, F-94205 Ivry, France
[2] INRA Met Risk, F-75231 Paris 5, France
关键词
Household surveys; individualization; linear MIXED model; risk assessment; spline estimation; METHYL MERCURY; INFORMATION; TIME; FISH;
D O I
10.1177/1471082X0800900103
中图分类号
O21 [概率论与数理统计]; C8 [统计学];
学科分类号
020208 ; 070103 ; 0714 ;
摘要
Foods naturally contain a number of contaminants that may have different and long-term toxic effects. This paper introduces a novel approach for the assessment of such chronic food risk that integrates the pharmakokinetic properties of a given contaminant. The estimation of such a Kinetic Dietary Exposure Model (KDEM) should be based on long-term consumption data which, for the moment, can only be provided by Household Budget Surveys such as the TNS SECODIP panel in France. A semi-parametric model is proposed to decompose a series of household quantities into individual quantities which are then used as inputs of the KDEM. As an illustration, the risk assessment related to the presence of methylmercury in seafoods is revisited using this novel approach.
引用
收藏
页码:27 / 50
页数:24
相关论文
共 34 条
[31]  
TRESSOU J, 2005, THESIS U PARIS 10
[32]   Nonparametric estimation of individual food availability along with bootstrap confidence intervals in household budget surveys [J].
Vasdekis, VGS ;
Trichopoulou, A .
STATISTICS & PROBABILITY LETTERS, 2000, 46 (04) :337-345
[33]  
Verbyla A., 1999, Mixed models for practitioners
[34]   Integration of time as a description parameter in risk characterisation:: Application to methyl mercury [J].
Verger, Ph. ;
Tressou, J. ;
Clemencon, S. .
REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2007, 49 (01) :25-30