Circular RNA hsa-circ-0016347 promotes proliferation, invasion and metastasis of osteosarcoma cells

被引：98

作者：

Jin, Hao ^{[1
]}

Jin, Xin ^{[2
]}

Zhang, Hong ^{[2
]}

Wang, Wenbo ^{[1
]}

机构：

[1] Harbin Med Univ, Affiliated Hosp 1, Dept Orthopaed, Harbin, Heilongjiang Pr, Peoples R China

[2] Harbin Med Univ, Affiliated Hosp 1, Dept Ophthalmol, Harbin, Heilongjiang Pr, Peoples R China

来源：

ONCOTARGET | 2017年 / 8卷 / 15期

关键词：

circ-0016347; mir-214; caspase-1; osteosarcoma; therapy; MIR-214; PROMOTES; TUMOR-GROWTH; MOUSE MODEL; EXPRESSION; MICRORNAS; IDENTIFICATION; PROGRESSION; ACTIVATION; PROGNOSIS; SURVIVAL;

D O I：

10.18632/oncotarget.16104

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Circular RNAs (circRNAs) are a novel class of non-coding RNA which have recently shown huge capabilities in the regulation of gene expression at the post-transcriptional level. Growing evidence has indicated that circRNAs could serve as competing endogenous RNAs (ceRNAs) to bind with microRNAs (miRNAs) and to inhibit the activity and function of the targeted miRNAs. Here, we demonstrated that circ-0016347 acted as a positive regulator in osteosarcoma cells proliferation and invasion. Moreover, circ-0016347 was identified as a sponge of miR-214 that upregulated the expression of caspase-1, which is the functional target of miR-214. Our study provides novel insight into the regulatory mechanism of circ-0016347 and its downstream targets in proliferation, invasion and metastasis of osteosarcoma cells, which will facilitate further development in the therapy of osteosarcoma.

引用

页码：25571 / 25581

页数：11

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