Steroid control of longevity in Drosophila melanogaster

被引：199

作者：

Simon, AF ^{[1
]}

Shih, C ^{[1
]}

Mack, A ^{[1
]}

Benzer, S ^{[1
]}

机构：

[1] CALTECH, Div Biol 156 29, Pasadena, CA 91125 USA

来源：

SCIENCE | 2003年 / 299卷 / 5611期

关键词：

D O I：

10.1126/science.1080539

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Ecdysone, the major steroid hormone of Drosophila melanogaster, is known for its role in development and reproduction. Flies that are heterozygous for mutations of the ecdysone receptor exhibit increases in life-span and resistance to various stresses, with no apparent deficit in fertility or activity. A mutant involved in the biosynthesis of ecdysone displays similar effects, which are suppressed by feeding ecdysone to the flies. These observations demonstrate the importance of the ecdysone hormonal pathway, a new player in regulating longevity.

引用

页码：1407 / 1410

页数：5

共 24 条

[1] Steroid regulation of programmed cell death during Drosophila development [J].