Fifteen-year quest for microphthalmia-associated transcription factor target genes

被引：345

作者：

Cheli, Yann ^{[1
]}

Ohanna, Mickael ^{[1
]}

Ballotti, Robert ^{[1
]}

Bertolotto, Corine ^{[1
]}

机构：

[1] INSERM, U895, Equipe 1, Nice 2, France

来源：

PIGMENT CELL & MELANOMA RESEARCH | 2010年 / 23卷 / 01期

关键词：

microphthalmia-associated transcription factor; targets; melanocytes; melanoma; mast cells; osteoclasts; CULTURED MAST-CELLS; WAARDENBURG SYNDROME TYPE-2; MELANOCYTE-SPECIFIC EXPRESSION; NERVE GROWTH-FACTOR; FACTOR MITF; TYROSINE KINASE; MUTANT MICE; CYCLIC-AMP; IMPAIRED EXPRESSION; SIGNAL-TRANSDUCTION;

D O I：

10.1111/j.1755-148X.2009.00653.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Microphthalmia-associated transcription factor (MITF) was initially shown to play a key role in melanocyte differentiation through the direct transcriptional control of TYROSINASE, TYRP1 and DCT genes, encoding the three enzymes involved in melanin synthesis or melanogenesis. Sixteen years after the first description of MITF, more than 40 direct MITF target genes have been described. They play a key role in melanocyte, osteoclast and mast cell specific functions. Furthermore, several MITF target genes, e.g. BCL2, CDK2, CDKN1A, CDKN2A, MET and HIF1A, link MITF to general cellular processes such as growth or survival. In this review, we provide an overview of the MITF-regulated genes. We pay special attention to the MITF target genes in melanocytes and raise questions about target specificity.

引用

页码：27 / 40

页数：14

共 141 条

[1]

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