Cardioprotective effect of squalene on lipid profile in isoprenaline-induced myocardial infarction in rats

被引：57

作者：

Farvin, K. H. Sabeena ^{[1
]}

Anandan, R. ^{[1
]}

Kumar, S. Hari Senthil ^{[1
]}

Shiny, K. S. ^{[1
]}

Mathew, Suseela ^{[1
]}

Sankar, T. V. ^{[1
]}

Nair, P. G. Viswanathan ^{[1
]}

机构：

[1] Cent Inst Fisheries Technol, Biochem & Nutr Div, Cochin 682029, Kerala, India

来源：

JOURNAL OF MEDICINAL FOOD | 2006年 / 9卷 / 04期

关键词：

isoprenaline; lipid peroxidation; lipids; myocardial infarction; squalene;

D O I：

10.1089/jmf.2006.9.531

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

We Studied the cardioprotective effect of squalene on isoprenaline-induced myocardial infarction in male albino rats with respect to changes in the levels of lipid components in plasma and heart tissue. Prior administration of 2% squalene in feed for 45 days significantly reduced the isoprenaline-induced elevation in the levels of cholesterol, triglyccrides, and free fatty acids in plasma and heart tissue of rats following myocardial infarction. It exerted an anitlipidemic effect by reducing the level of low-density lipoprotein cholesterol with a parallel rise in the level of high-density lipoprotein cholesterol in plasma of experimental rats. A tendency to prevent the isoprenaline-induced depletion of phospholipids in the myocardium of experimental rats was also observed. In the present study, the pretreatment with squalene significantly Counteracted the isoprenaline-induced lipid peroxidation and maintained the rats at near normal status. The results of the present study indicate that the overall cardioprotective effect of squalene is probably related to an inhibition of lipid accumalation by its hypolipidemic properties and/or its antioxidant properties.

引用

页码：531 / 536

页数：6

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