Acute hemorrhagic leukoencephalitis: Recovery and reversal of magnetic resonance imaging findings in a child

被引:43
作者
Rosman, NP
Gottlieb, SM
Bernstein, CA
机构
[1] FLOATING HOSP CHILDREN,DIV PEDIAT NEUROL,DEPT NEUROL,BOSTON,MA 02111
[2] TUFTS UNIV NEW ENGLAND MED CTR,DEPT NEUROL,BOSTON,MA 02111
关键词
D O I
10.1177/088307389701200707
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
A case of acute hemorrhagic. leukoencephalitis (AHLE) in a 6-year-old girl is reported. The presentation was typical for acute hemorrhagic leukoencephalitis, with acute onset of a rapidly progressive neurologic disorder with asymmetric involvement of brain, with polymorphonuclear predominant peripheral leukocytosis and cerebrospinal fluid pleocytosis. Cerebrospinal fluid findings not previously reported included elevation of IgG and the presence of myelin basic protein. Additional previously unreported findings were striking abnormalities on magnetic resonance imaging (MRI) of the brain, in contrast to normal findings on computed tomography (CT). The child was treated with high dose intravenous steroids and made a full recovery, with a parallel disappearance of all of her cerebrospinal fluid abnormalities and almost all of her abnormalities on MRI. Detailed examination of cerebrospinal fluid and MRI of brain should facilitate early diagnosis in other cases of suspected acute hemorrhagic leukoencephalitis and high-dose steroid therapy may lead to improved clinical outcomes.
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页码:448 / 454
页数:7
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