Aberrant localization of importin α1 in hippocampal neurons in Alzheimer disease

被引：49

作者：

Lee, Hyoung-gon

Ueda, Masumi

Miyamoto, Yoichi

Yoneda, Yoshihiro

Perry, George

Smith, Mark A.

Zhu, Xiongwei

机构：

[1] Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA

[2] Osaka Univ, Dept Frontier Biosci, Grad Sch Frontier Biosci, Suita, Osaka 5650871, Japan

[3] Univ Texas, Coll Sci, San Antonio, TX 78249 USA

来源：

BRAIN RESEARCH | 2006年 / 1124卷

基金：

美国国家卫生研究院;

关键词：

Alzheimer disease; cytoplasmic-nuclear transport; hirano body; importin;

D O I：

10.1016/j.brainres.2006.09.084

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Since many nuclear proteins are ectopically localized in the cytoplasm in the vulnerable neurons in Alzheimer disease (AD), we speculated that there is failure of the cytoplasmic-nuclear transport machinery in AD. In support of this notion, we found that importin alpha 1, an essential component of cytoplasmic-nuclear transport, is abnormally accumulated in Hirano bodies in vulnerable hippocampal neurons in AD. These data suggest a hindrance in importin-mediated cytoplasmic-nuclear transport in AD. (c) 2006 Elsevier B.V. All rights reserved.

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页码：1 / 4

页数：4

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