Gabapentin withdrawal presenting as status epilepticus

被引:33
作者
Barrueto, F
Green, J
Howland, MA
Hoffman, RS
Nelson, LS
机构
[1] New York City Poison Control Ctr, New York, NY 10016 USA
[2] NYU, Sch Med, Dept Emergency Med, New York, NY USA
[3] Staten Isl Univ Hosp, Dept Internal Med, New York, NY USA
[4] St Johns Univ, Coll Pharm, Jamaica, NY 11439 USA
来源
JOURNAL OF TOXICOLOGY-CLINICAL TOXICOLOGY | 2002年 / 40卷 / 07期
关键词
gabapentin; anticonvulsants; seizure; withdrawal; epilepsy;
D O I
10.1081/CLT-120016965
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
A 34-year-old male with lumbar disc disease and surgery was placed on gabapentin daily for chronic back pain. He remained on a steady dose of 8000 mg/day for 9 months, almost doubled what is considered therapeutic. He ran out of medication, was unable to refill his prescription for 2 days and presented to the emergency department in status epilepticus. There was no previous history of seizure disorder and he was on no other medications. A medical evaluation for an alternative etiology of his seizures was negative. Although gabapentin withdrawal has been previously reported and usually consists of anxiety, diaphoresis, and palpitations, this is the first reported patient with generalized seizures and status epilepticus secondary to gabapentin withdrawal.
引用
收藏
页码:925 / 928
页数:4
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