Isolation and characterization of a novel presenilin binding protein

被引：60

作者：

Kashiwa, A

Yoshida, H

Lee, S

Paladino, T

Liu, YB

Chen, Q

Dargusch, R

Schubert, D

Kimura, H

机构：

[1] Univ Calif, Salk Inst Biol Studies, La Jolla, CA 92037 USA

[2] Univ Calif, Dept Pathol, La Jolla, CA USA

来源：

JOURNAL OF NEUROCHEMISTRY | 2000年 / 75卷 / 01期

关键词：

Alzheimer's disease; presenilin; presenilin binding protein;

D O I：

10.1046/j.1471-4159.2000.0750109.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Approximately 50% of familial Alzheimer's disease (AD) cases are linked to the presenilin (PS) gene. This suggests that an altered function of mutated PSs accounts for a fundamental process leading to AD. Here we identify a new PS binding protein, PBP, which is highly expressed in cerebral cortex and hippocampus. Immunohistochemical studies and cell fractionation analysis show that PBP redistributes from cytoplasm to membranes in the presence of PS. In addition, PBP is deficient in the soluble fraction of sporadic AD brains.

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页码：109 / 116

页数：8

相关论文

共 19 条

[1] NEUROFIBRILLARY TANGLES IN ALZHEIMERS-DISEASE AND PROGRESSIVE SUPRANUCLEAR PALSY - ANTIGENIC SIMILARITIES AND DIFFERENCES - MICROTUBULE-ASSOCIATED PROTEIN-TAU ANTIGENICITY IS PROMINENT IN ALL TYPES OF TANGLES [J].

BANCHER, C ;

LASSMANN, H ;

BUDKA, H ;

GRUNDKEIQBAL, I ;

IQBAL, K ;

WICHE, G ;

SEITELBERGER, F ;

WISNIEWSKI, HM .

ACTA NEUROPATHOLOGICA, 1987, 74 (01) :39-46

[2]

BUSCIGLIO J, 1997, J NEUROSCI, V17, P5010

[3] Calsenilin: A calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment [J].

Buxbaum, JD ;

Choi, EK ;

Luo, YX ;

Lilliehook, C ;

Crowley, AC ;

Merriam, DE ;

Wasco, W .

NATURE MEDICINE, 1998, 4 (10) :1177-1181

[4] Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation [J].

Chui, DH ;

Tanahashi, H ;

Ozawa, K ;

Ikeda, S ;

Checler, F ;

Ueda, O ;

Suzuki, H ;

Araki, W ;

Inoue, H ;

Shirotani, K ;

Takahashi, K ;

Gallyas, F ;

Tabira, T .

NATURE MEDICINE, 1999, 5 (05) :560-564

[5] Protein topology of presenilin 1 [J].

Doan, A ;

Thinakaran, G ;

Borchelt, DR ;

Slunt, HH ;

Ratovitsky, T ;

Podlisny, M ;

Selkoe, DJ ;

Seeger, M ;

Gandy, SE ;

Price, DL ;

Sisodia, SS .

NEURON, 1996, 17 (05) :1023-1030

[6]

Hasegawa H, 1996, MOL CELL BIOL, V16, P1770

[7] EXPRESSION OF THE V-CRK ONCOGENE PRODUCT IN PC12 CELLS RESULTS IN RAPID DIFFERENTIATION BY BOTH NERVE GROWTH FACTOR-AND EPIDERMAL GROWTH FACTOR-DEPENDENT PATHWAYS [J].

HEMPSTEAD, BL ;

BIRGE, RB ;

FAJARDO, JE ;

GLASSMAN, R ;

MAHADEO, D ;

KRAEMER, R ;

HANAFUSA, H .

MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (03) :1964-1971

[8] ADVANCES IN ALZHEIMERS-DISEASE [J].

KATZMAN, R ;

SAITOH, T .

FASEB JOURNAL, 1991, 5 (03) :278-286

[9]

Keller JN, 1998, J NEUROSCI, V18, P4439

[10] SCHWANNOMA-DERIVED GROWTH-FACTOR MUST BE TRANSPORTED INTO THE NUCLEUS TO EXERT ITS MITOGENIC ACTIVITY [J].

KIMURA, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (06) :2165-2169