Is High Consumption of Antibiotics Associated with Clostridium difficile Polymerase Chain Reaction-Ribotype 027 Infections in France?

被引：6

作者：

Birgand, Gabriel ^{[2
]}

Miliani, Katiuska ^{[2
]}

Carbonne, Anne ^{[2
]}

Astagneau, Pascal ^{[1
,2
]}

机构：

[1] Univ Paris 06, Ctr Cordeliers, C CLIN Paris Nord, Dept Epidemiol & Publ Hlth,Sch Med, F-75006 Paris, France

[2] Reg Coordinating Ctr Nosocomial Infect Control, Paris, France

来源：

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY | 2010年 / 31卷 / 03期

关键词：

NORTH-AMERICA; RISK-FACTOR; DISEASE; EPIDEMIC; OUTBREAK; DIARRHEA; EMERGENCE; STRAIN;

D O I：

10.1086/650758

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

We compared antibiotic consumption between hospitals affected by a strain of Clostridium difficile designated as polymerase chain reaction- ribotype 027 (CD-027) and those unaffected during an outbreak in northern France. The mean consumption of several beta-lactams, amikacin, and fluoroquinolones was high in affected hospitals (P < .05). However, only levofloxacin and imipenem remained associated with emerging CD-027 in the multivariate analysis, suggesting that those antibiotics should be better targeted by prevention campaigns. Infect Control Hosp Epidemiol 2010;31:302-305

引用

页码：302 / 305

页数：4

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