Stereochemistry and total synthesis of janolusimide, a tripeptide marine toxin

被引：13

作者：

Giordano, A ^{[1
]}

Della Monica, C ^{[1
]}

Landi, F ^{[1
]}

Spinella, A ^{[1
]}

Sodano, G ^{[1
]}

机构：

[1] Univ Salerno, Dipartimento Chim, I-84081 Baronissi, SA, Italy

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 20期

关键词：

marine metabolites; molluscs; peptides; imides;

D O I：

10.1016/S0040-4039(00)00533-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The stereochemistry of janolusimide, a lipophilic tripeptide marine toxin, has been fully elucidated by stereoselective synthesis of the lactam component (5S)-3,3'-dimethyl-5-isopropylpyrrolidin-2,4-dione. The peptide was then synthesized in 13 steps and in 0.8% total yield. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：3979 / 3982

页数：4

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