Collecting and organizing systematic sets of protein data

被引:73
作者
Albeck, John G.
MacBeath, Gavin
White, Forest M.
Sorger, Peter K.
Lauffenburger, Douglas A.
Gaudet, Suzanne
机构
[1] MIT, Dept Biol Engn, Ctr Cell Decis, Cambridge, MA 02139 USA
[2] Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA USA
[3] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1038/nrm2042
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Systems biology, particularly of mammalian cells, is data starved. However, technologies are now in place to obtain rich data, in a form suitable for model construction and validation, that describes the activities, states and locations of cell-signalling molecules. The key is to use several measurement technologies simultaneously and, recognizing each of their limits, to assemble a self-consistent compendium of systematic data.
引用
收藏
页码:803 / 812
页数:10
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