Regulation of cell death by the ubiquitin-proteasome system

被引：63

作者：

Bader, Maya ^{[1
]}

Steller, Hermann ^{[1
]}

机构：

[1] Rockefeller Univ, Howard Hughes Med Inst, New York, NY 10021 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2009年 / 21卷 / 06期

关键词：

ALPHA-DEPENDENT APOPTOSIS; NF-KAPPA-B; CASPASE ACTIVITY; CYTOCHROME-C; DISTINCT CASPASES; LIGASE ACTIVITY; DIAP2; FUNCTIONS; ARTS PROTEIN; DROSOPHILA; IAP;

D O I：

10.1016/j.ceb.2009.09.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The regulation of apoptosis (programmed cell death) has been the subject of a vast body of research because of its implications in normal development, tissue homeostasis and a wide range of diseases. The ubiquitin-proteasome system (UPS) plays a prominent role in the control of apoptosis by targeting key cell death proteins, including caspases, the central executioners of apoptosis. Here we summarize the major findings on the function of the UPS in both pro- and anti-apoptotic regulation.

引用

页码：878 / 884

页数：7

共 72 条

[1] Death without caspases, caspases without death [J].

Abraham, MC ;

Shaham, S .

TRENDS IN CELL BIOLOGY, 2004, 14 (04) :184-193

[2] The two Drosophila cytochrome C proteins can function in both respiration and caspase activation [J].

Arama, E ;

Bader, M ;

Srivastava, M ;

Bergmann, A ;

Steller, H .

EMBO JOURNAL, 2006, 25 (01) :232-243

[3] Caspase activity and a specific cytochrome c are required for sperm differentiation in Drosophila [J].

Arama, E ;

Agapite, J ;

Steller, H .

DEVELOPMENTAL CELL, 2003, 4 (05) :687-697

[4]

Arama E, 2007, PLOS BIOL, V5, P2745, DOI 10.1371/journal.pbio.0050251

[5] cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination [J].

Bertrand, Mathieu J. M. ;

Milutinovic, Snezana ;

Dickson, Kathleen M. ;

Ho, Wai Chi ;

Boudreault, Alain ;

Durkin, Jon ;

Gillard, John W. ;

Jaquith, James B. ;

Morris, Stephen J. ;

Barker, Philip A. .

MOLECULAR CELL, 2008, 30 (06) :689-700

[6] Activity-dependent dynamics and sequestration of proteasomes in dendritic spines [J].

Bingol, Baris ;

Schuman, Erin M. .

NATURE, 2006, 441 (7097) :1144-1148

[7] Ubiquitin-mediated regulation of apoptosis [J].

Broemer, Melke ;

Meier, Pascal .

TRENDS IN CELL BIOLOGY, 2009, 19 (03) :130-140

[8] Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination [J].

Chai, JJ ;

Yan, N ;

Huh, JR ;

Wu, JW ;

Li, WY ;

Hay, BA ;

Shi, YG .

NATURE STRUCTURAL BIOLOGY, 2003, 10 (11) :892-898

[9] The RING domain of cIAP1 mediates the degradation of RING-bearing Inhibitor of Apoptosis proteins by distinct pathways [J].

Cheung, Herman H. ;

Plenchette, Stephanie ;

Kern, Chris J. ;

Mahoney, Douglas J. ;

Korneluk, Robert G. .

MOLECULAR BIOLOGY OF THE CELL, 2008, 19 (07) :2729-2740

[10] ATP-DEPENDENT CONJUGATION OF RETICULOCYTE PROTEINS WITH THE POLYPEPTIDE REQUIRED FOR PROTEIN-DEGRADATION [J].

CIECHANOVER, A ;

HELLER, H ;

ELIAS, S ;

HAAS, AL ;

HERSHKO, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (03) :1365-1368

← 1 2 3 4 5 6 7 8 →