Oxygen tension in isolated transplanted rat islets and in islets of rat whole-pancreas transplants

被引：26

作者：

Carlsson, PO

Palm, F

机构：

[1] Biomed Ctr, Dept Med Cell Biol, S-75123 Uppsala, Sweden

[2] Uppsala Univ, Dept Med Cell Biol, Uppsala, Sweden

[3] Uppsala Univ, Dept Diagnost Radiol, Uppsala, Sweden

来源：

TRANSPLANT INTERNATIONAL | 2002年 / 15卷 / 11期

关键词：

angiogenesis; pancreas transplantation; cell transplantation; polarographic technique;

D O I：

10.1007/s00147-002-0460-7

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Despite similar immunosuppressive protocols having been applied, the success rate of pancreatic islet transplantation has been much lower than that of whole-pancreas transplantation. We compared the oxygen tension in syngeneically transplanted isolated rat islets and islets of syngeneic rat whole-pancreatic grafts, with native islets, using Clark-type microelectrodes. An oxygen tension of similar to40 mmHg was recorded in both native islets and in islets of the whole-pancreas graft. Isolated islets transplanted under the renal capsule had a markedly lower oxygen tension (similar to6 mmHg). The exocrine parenchyma of the native and of the transplanted pancreatic gland had an oxygen tension of similar to30 mmHg. The lower oxygen tension in transplanted isolated islets may be one explanation for the more frequent failures of transplanted islets compared with the outcome when the whole pancreatic gland is transplanted.

引用

页码：581 / 585

页数：5

共 32 条

[1]

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