Actinide speciation in relation to biological processes

被引:185
作者
Ansoborlo, Eric
Prat, Odette
Moisy, Philippe
Den Auwer, Christophe
Guilbaud, Philippe
Carriere, M.
Gouget, Barbara
Duffield, John
Doizi, Denis
Vercouter, Thomas
Moulin, Christophe
Moulin, Valerie
机构
[1] VRH Marcoule, CETAMA, DRCP, DEN,CEA, F-30207 Bagnols Sur Ceze, France
[2] VRH Marcoule, SBTN, DIEP, DSV,CEA, F-30207 Bagnols Sur Ceze, France
[3] VRH Marcoule, SCPS, DRCP, DEN,CEA, F-30207 Bagnols Sur Ceze, France
[4] LPS, DRECAM, DSM, CEA, F-91191 Gif Sur Yvette, France
[5] Univ W England, DCPS, Bristol BS16 1QY, Avon, England
[6] SECR, DPC, DEN, CEA, F-91191 Gif Sur Yvette, France
[7] MR, DDIN, DEN, CEA, F-91191 Gif Sur Yvette, France
关键词
actinide biochemistry; actinide chemistry; speciation; toxicology; bioavailability;
D O I
10.1016/j.biochi.2006.06.011
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In case of accidental release of radionuclides into the environment, actinides represent a severe health risk to human beings following internal contamination (inhalation, ingestion or wound). For a better understanding of the actinide behaviour in man (in term of metabolism, retention, excretion) and in specific biological systems (organs, cells or biochemical pathways), it is of prime importance to have a good knowledge of the relevant actinide solution chemistry and biochemistry, in particular of the thermodynamic constants needed for computing actinide speciation. To a large extent, speciation governs bioavailability and toxicity of elements and has a significant impact on the mechanisms by which toxics accumulate in cell compartments and organs and by which elements are transferred and transported from cell to cell. From another viewpoint, speciation is the prerequisite for the design and success of potential decorporation therapies. The purpose of this review is to present the state of the art of actinide knowledge within biological media. It is also to discuss how actinide speciation can be determined or predicted and to highlight the areas where information is lacking with the aim to encourage new research efforts. (c) 2006 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:1605 / 1618
页数:14
相关论文
共 123 条
[1]  
*AEN, 1999, AEN WORKSH P TOK MUR
[2]  
AISEN P, 1978, J BIOL CHEM, V253, P1930
[3]   EXPECTED SPECIES OF URANIUM, NEPTUNIUM AND PLUTONIUM IN NEUTRAL AQUEOUS-SOLUTIONS [J].
ALLARD, B ;
KIPATSI, H ;
LILJENZIN, JO .
JOURNAL OF INORGANIC & NUCLEAR CHEMISTRY, 1980, 42 (07) :1015-1027
[4]  
Allard B., 1997, MODELLING AQUATIC CH
[5]  
ALLEN PG, 1996, SYNCHROTRON RAD TECH
[6]  
[Anonymous], 1995, CHEM THERMODYNAMICS
[7]   Ligand binding affinities from MD simulations [J].
Åqvist, J ;
Luzhkov, VB ;
Brandsdal, BO .
ACCOUNTS OF CHEMICAL RESEARCH, 2002, 35 (06) :358-365
[8]   Metallogenomics and biological X-ray absorption spectroscopy [J].
Ascone, I ;
Fourme, R ;
Hasnain, S ;
Hodgson, K .
JOURNAL OF SYNCHROTRON RADIATION, 2005, 12 :1-3
[9]   Molecular dynamics study of the uranyl extraction by tri-n-butylphosphate (TBP):: Demixing of water/"oil"/TBP solutions with a comparison of supercritical CO2 and chloroform [J].
Baaden, M ;
Schurhammer, R ;
Wipff, G .
JOURNAL OF PHYSICAL CHEMISTRY B, 2002, 106 (02) :434-441
[10]   Applications of gene arrays in environmental toxicology:: Fingerprints of gene regulation associated with cadmium chloride, benzo(a)pyrene, and trichloroethylene [J].
Bartosiewicz, M ;
Penn, S ;
Buckpitt, A .
ENVIRONMENTAL HEALTH PERSPECTIVES, 2001, 109 (01) :71-74