BRCA1 and its toolbox for the maintenance of genome integrity

被引：397

作者：

Huen, Michael S. Y. ^{[2
,3
]}

Sy, Shirley M. H. ^{[2
]}

Chen, Junjie ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Expt Radiat Oncol, Houston, TX 77030 USA

[2] Univ Hong Kong, Dept Anat, Hong Kong, Hong Kong, Peoples R China

[3] Univ Hong Kong, Canc Res Ctr, Hong Kong, Hong Kong, Peoples R China

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2010年 / 11卷 / 02期

基金：

美国国家卫生研究院;

关键词：

DNA-DAMAGE RESPONSE; HISTONE H2AX PHOSPHORYLATION; HOMOLOGY-DIRECTED REPAIR; DOMAIN BARD1 GENE; INTERACT IN-VIVO; FANCONI-ANEMIA; UBIQUITIN LIGASE; S-PHASE; BRCA1/BARD1; HETERODIMER; POLYUBIQUITIN CHAINS;

D O I：

10.1038/nrm2831

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The breast and ovarian cancer type 1 susceptibility protein (BRCA1) has pivotal roles in the maintenance of genome stability. Studies support that BRCA1 exerts its tumour suppression function primarily through its involvement in cell cycle checkpoint control and DNA damage repair. In addition, recent proteomic and genetic studies have revealed the presence of distinct BRCA1 complexes in vivo, each of which governs a specific cellular response to DNA damage. Thus, BRCA1 is emerging as the master regulator of the genome through its ability to execute and coordinate various aspects of the DNA damage response.

引用

页码：138 / 148

页数：11

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